ADAMTSL5
ADAMTS-like protein 5
Protein Summary
May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).
- ENST00000413997
- ENSP00000399364
- ENSG00000185761
- THSD6
- THSD6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
tissue sample | 0.68 | ||
transcription factor perturbation | 0.68 | ||
histone modification site profile | 0.67 | ||
molecular function | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.21 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.21 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 1 | 1 | 13.5 | |||||
hematocrit | 1 | 1 | 1 | 13.5 | |||||
pulse pressure measurement | 1 | 1 | 1 | 12.6 | |||||
Urinary retention | 1 | 1 | 0 | 7.8 | 3.7 | ||||
response to radiation | 1 | 1 | 0 | 7.8 | 3.7 | ||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 13.5 | |||||
hematocrit | 1 | 13.5 | |||||
pulse pressure measurement | 1 | 12.6 | |||||
Urinary retention | 0 | 7.8 | 3.7 | ||||
response to radiation | 0 | 7.8 | 3.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ADAMTS like 5 | VGNC:2085 | 742967 | |||||
Macaque | ADAMTS like 5 | 721290 | ||||||
Mouse | MGI:1913798 | 66548 | ||||||
Dog | ADAMTS like 5 | VGNC:37609 | 485082 | |||||
Horse | ADAMTS like 5 | VGNC:50328 | 100060620 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ADAMTS like 5 | |||||
Macaque | ADAMTS like 5 | |||||
Mouse | ||||||
Dog | ADAMTS like 5 | |||||
Horse | ADAMTS like 5 | |||||
Publication Statistics
PubMed Score 7.21
PubMed score by year
PubTator Score 4.75
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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