Tbio ADAMTSL5 ADAMTS-like protein 5

Protein Summary

Description

May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).

Uniprot Accession IDs

• Q6ZMM2
• B4DXK7
• Q8IW95
• ADAMTSL-5

Gene Name

• ADAMTSL5

Ensembl ID

• ENST00000413997
• ENSP00000399364
• ENSG00000185761

Symbol

• THSD6
• THSD6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
tissue sample	0.68
transcription factor perturbation	0.68
histone modification site profile	0.67
molecular function	0.67

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Adamts-like Protein 5

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Adamts-like Protein 5

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Adamts-like Protein 5

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Adamts-like Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.72   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.72   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0