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Tdark
CYHR1
Cysteine and histidine-rich protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306145
  • ENSP00000304826
  • ENSG00000187954
  • ENST00000403000
  • ENSP00000385962
  • ENST00000424149
  • ENSP00000414647
  • ENST00000438911
  • ENSP00000387426

Symbol
  • KIAA0496
  • CHRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.88
transcription factor perturbation
0.88
small molecule perturbation
0.73
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8
94.2
mathematical ability
4
4
4
93.4
sex hormone-binding globulin measurement
6
2
6
90.7
self reported educational attainment
5
3
4
5.9
90.6
red blood cell distribution width
2
2
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8
94.2
mathematical ability
4
93.4
sex hormone-binding globulin measurement
6
90.7
self reported educational attainment
4
5.9
90.6
red blood cell distribution width
2
83
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine and histidine rich 1
VGNC:11963
464465
Macaque
cysteine and histidine rich 1
702522
Mouse
MGI:1859320
54151
Rat
RGD:2318728
100362155
Dog
cysteine and histidine rich 1
VGNC:50290
609854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine and histidine rich 1
Macaque
cysteine and histidine rich 1
Mouse
Rat
Dog
cysteine and histidine rich 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZMK1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (40)
1 – 10 of 40
UBE2K
Tbio
Novelty:  0.00214955
p_int:  0.999999991
p_ni:  7e-9
p_wrong:  2e-9
Score:  0.494
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.999996392
p_ni:  0.000002859
p_wrong:  7.49e-7
Data Source:  BioPlex
DNAJB2
Tbio
Novelty:  0.046216
p_int:  0.999980154
p_ni:  0.000019846
Score:  0.2
Data Source:  BioPlex,STRINGDB
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.999846054
p_ni:  0.000125469
p_wrong:  0.000028477
Data Source:  BioPlex
LRRC73
Tdark
Novelty:  48
p_int:  0.999791709
p_ni:  0.000206256
p_wrong:  0.000002035
Data Source:  BioPlex
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.999722829
p_ni:  0.000275122
p_wrong:  0.000002049
Data Source:  BioPlex
EPN3
Tbio
Novelty:  0.12685855
p_int:  0.999187636
p_ni:  0.000669742
p_wrong:  0.000142622
Score:  0.2
Data Source:  BioPlex,STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.98972499
p_ni:  0.003604128
p_wrong:  0.006670883
Data Source:  BioPlex
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.987022426
p_ni:  0.000346858
p_wrong:  0.012630716
Score:  0.363
Data Source:  BioPlex,STRINGDB
SLC45A2
Tbio
Family:  Transporter
Novelty:  0.00268252
p_int:  0.939471046
p_ni:  0.060049585
p_wrong:  0.000479369
Score:  0.19
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.21

PubMed score by year
PubTator Score  6.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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