Protein Summary
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
- ENST00000288098
- ENSP00000288098
- ENSG00000157368
- ENST00000429149
- ENSP00000397863
- C16orf77
- IL-34
- C16orf77
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.6 | ||
tissue sample | 0.53 | ||
cell type or tissue | 0.51 | ||
PubMedID | 0.5 | ||
biological process | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.66 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 350 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.66 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 350 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (35)
Nearest Tclin Targets
Pathways (6)
Reactome (4)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Other interleukin signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Other interleukin signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (2)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cognitive function measurement | 3 | 2 | 4 | 61.8 | |||||
red blood cell density measurement | 1 | 1 | 1 | 52.4 | |||||
hemoglobin measurement | 1 | 1 | 1 | 50.6 | |||||
self reported educational attainment | 1 | 1 | 1 | 44.2 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cognitive function measurement | 4 | 61.8 | |||||
red blood cell density measurement | 1 | 52.4 | |||||
hemoglobin measurement | 1 | 50.6 | |||||
self reported educational attainment | 1 | 44.2 | |||||
alkaline phosphatase measurement | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 34 | VGNC:5809 | 454217 | |||||
Macaque | interleukin 34 | 709034 | ||||||
Mouse | MGI:1923777 | 76527 | ||||||
Rat | RGD:1586038 | 498951 | ||||||
Dog | interleukin 34 | VGNC:41983 | 610536 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 34 | |||||
Macaque | interleukin 34 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 34 | |||||
Publication Statistics
PubMed Score 172.66
PubMed score by year
PubTator Score 65.56
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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