Tbio SLC39A5 Zinc transporter ZIP5

Protein Summary

Description

May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity). The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q6ZMH5
• B2R808
• Q8N6Y3

Gene Name

• SLC39A5

Ensembl ID

• ENST00000266980
• ENSP00000266980
• ENSG00000139540
• ENST00000454355
• ENSP00000405360

Symbol

• ZIP5
• ZIP5
• MYP24
• LZT-Hs7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.62
cell line	0.62
tissue sample	0.62
cell type or tissue	0.6
cellular component	0.6

Protein Classes

PANTHER Classes

Protein / Transporter / Zinc Transporter Zip5

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc39 Family Of Metal Ion Transporters / Zinc Transporter Zip5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.32   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.32   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0