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Tbio
SLC39A5
Zinc transporter ZIP5

Protein Summary
Description
May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity). The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266980
  • ENSP00000266980
  • ENSG00000139540
  • ENST00000454355
  • ENSP00000405360

Symbol
  • ZIP5
  • ZIP5
  • MYP24
  • LZT-Hs7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.62
cell line
0.62
tissue sample
0.62
cell type or tissue
0.6
cellular component
0.6


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
8
9
99.5
inflammatory skin disease
1
1
0
1.5
53.7
risk-taking behaviour
1
1
1
33.1
BMI-adjusted waist circumference
1
1
1
30.2
C-reactive protein measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
99.5
inflammatory skin disease
0
1.5
53.7
risk-taking behaviour
1
33.1
BMI-adjusted waist circumference
1
30.2
C-reactive protein measurement
1
21.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 5
VGNC:8542
451991
Mouse
MGI:1919336
72002
Rat
RGD:1310322
362812
Horse
solute carrier family 39 member 5
VGNC:23205
100052215
Cow
solute carrier family 39 member 5
VGNC:34865
511782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 5
Mouse
Rat
Horse
solute carrier family 39 member 5
Cow
solute carrier family 39 member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZMH5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc influx into cells by the SLC39 gene family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc influx into cells by the SLC39 gene family
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (100)
1 – 10 of 100
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.999997892
p_ni:  0.000002108
Data Source:  BioPlex
HLA-A
Tbio
Novelty:  0.00270731
p_int:  0.999945613
p_ni:  0.000054387
Data Source:  BioPlex
RYK
Tbio
Family:  Kinase
Novelty:  0.00910227
p_int:  0.999939867
p_ni:  0.000046687
p_wrong:  0.000013447
Data Source:  BioPlex
METTL9
Tdark
Family:  Enzyme
Novelty:  0.20589257
p_int:  0.999877099
p_ni:  0.000122901
Data Source:  BioPlex
ULBP3
Tbio
Novelty:  0.0320239
p_int:  0.99984493
p_ni:  0.000147463
p_wrong:  0.000007608
Data Source:  BioPlex
PIP4P2
Tbio
Family:  Enzyme
Novelty:  0.94294105
p_int:  0.999837498
p_ni:  0.000053049
p_wrong:  0.000109453
Data Source:  BioPlex
SCARF2
Tbio
Novelty:  0.08833851
p_int:  0.999763217
p_ni:  0.000236307
p_wrong:  4.76e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
CYSTM1
Tdark
Novelty:  1.37759108
p_int:  0.998842501
p_ni:  0.000090257
p_wrong:  0.001067243
Score:  0.189
Data Source:  BioPlex,STRINGDB
SLC39A6
Tbio
Family:  Transporter
Novelty:  0.0144314
p_int:  0.99846738
p_ni:  0.00153262
Score:  0.451
Data Source:  BioPlex,STRINGDB
MIA3
Tbio
Novelty:  0.02784348
p_int:  0.998254814
p_ni:  0.001745186
Data Source:  BioPlex
Publication Statistics
PubMed Score  22.88

PubMed score by year
PubTator Score  9.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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