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Tbio
CERS6
Ceramide synthase 6

Protein Summary
Description
May be involved in sphingolipid synthesis or its regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305747
  • ENSP00000306579
  • ENSG00000172292
  • ENST00000392687
  • ENSP00000376453

Symbol
  • LASS6
  • CERS5
  • LASS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
kinase perturbation
0.96
transcription factor perturbation
0.94
transcription factor binding site profile
0.8
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.2   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.2   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (77)
1 – 10 of 77
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.99883455
p_ni:  0.001165448
p_wrong:  2e-9
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.992858068
p_ni:  0.007092783
p_wrong:  0.000049149
Data Source:  BioPlex
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.988892704
p_ni:  0.009519782
p_wrong:  0.001587514
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.987330265
p_ni:  0.012669538
p_wrong:  1.97e-7
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.973869187
p_ni:  0.026130655
p_wrong:  1.58e-7
Data Source:  BioPlex
RETREG3
Tdark
Novelty:  0.99215801
p_int:  0.969971243
p_ni:  0.012559408
p_wrong:  0.017469349
Score:  0.663
Data Source:  BioPlex,STRINGDB
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.966636671
p_ni:  0.018002442
p_wrong:  0.015360886
Score:  0.656
Data Source:  BioPlex,STRINGDB
LRCH1
Tbio
Novelty:  0.0923291
p_int:  0.963271444
p_ni:  0.036718163
p_wrong:  0.000010393
Data Source:  BioPlex
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.962852367
p_ni:  0.017099376
p_wrong:  0.020048257
Data Source:  BioPlex
TXNDC15
Tdark
Novelty:  0.23488442
p_int:  0.9402788
p_ni:  0.059502151
p_wrong:  0.000219049
Data Source:  BioPlex
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
1
12
12
97
HbA1c measurement
1
7
7
94.5
red blood cell distribution width
4
3
6
93.2
myeloid white cell count
2
2
2
91
monocyte count
3
2
3
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
12
97
HbA1c measurement
7
94.5
red blood cell distribution width
6
93.2
myeloid white cell count
2
91
monocyte count
3
90.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ceramide synthase 6
VGNC:131
741293
Macaque
ceramide synthase 6
704953
Mouse
MGI:2442564
241447
Rat
RGD:1561599
366065
Dog
ceramide synthase 6
VGNC:39152
488387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ceramide synthase 6
Macaque
ceramide synthase 6
Mouse
Rat
Dog
ceramide synthase 6
Publication Statistics
PubMed Score 68.20
PubMed score by year
PubTator Score 27.52
PubTator score by year