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Tbio
B3GNT6
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

Protein Classes
Protein Summary
Description
Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. The protein encoded by this gene is a beta-1,3-N-acetylglucosaminyltransferase that adds an N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine or threonine. The encoded enzyme is responsible for creating the core 3 structure of O-glycans, which are important components of mucin-type glycoproteins. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000622824
  • ENSP00000484640
  • ENSG00000198488

Symbol
  • BGnT-6
  • B3Gn-T6
  • beta3Gn-T6
  • beta-1,3-Gn-T6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.79
cell line
0.56
cellular component
0.55
gene perturbation
0.48
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (51)
1 – 10 of 51
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01514342
Score: 0.965
Data Source: STRINGDB
GCNT1
Tbio
Family: Enzyme
Novelty: 0.0114317
Score: 0.961
Data Source: STRINGDB
C1GALT1C1
Tbio
Family: Enzyme
Novelty: 0.00694171
Score: 0.957
Data Source: STRINGDB
GCNT3
Tbio
Family: Enzyme
Novelty: 0.04293454
Score: 0.955
Data Source: STRINGDB
ST6GALNAC1
Tbio
Family: Enzyme
Novelty: 0.00846998
Score: 0.949
Data Source: STRINGDB
MUC20
Tbio
Novelty: 0.07155729
Score: 0.94
Data Source: STRINGDB
MUC1
Tbio
Novelty: 0.00029046
Score: 0.926
Data Source: STRINGDB
MUC5B
Tbio
Novelty: 0.00088548
Score: 0.922
Data Source: STRINGDB
MUC6
Tbio
Novelty: 0.00438241
Score: 0.921
Data Source: STRINGDB
MUC4
Tbio
Novelty: 0.00238494
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.88

PubMed score by year
PubTator Score  6.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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