B3GNT6
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Protein Classes
Protein Summary
Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. The protein encoded by this gene is a beta-1,3-N-acetylglucosaminyltransferase that adds an N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine or threonine. The encoded enzyme is responsible for creating the core 3 structure of O-glycans, which are important components of mucin-type glycoproteins. [provided by RefSeq, Dec 2016]
- ENST00000622824
- ENSP00000484640
- ENSG00000198488
- BGnT-6
- B3Gn-T6
- beta3Gn-T6
- beta-1,3-Gn-T6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phenotype | 0.79 | ||
cell line | 0.56 | ||
cellular component | 0.55 | ||
gene perturbation | 0.48 | ||
protein complex | 0.4 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.88 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 88 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.88 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 88 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (7)
Reactome (4)
KEGG (2)
UniProt (1)
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Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | O-linked glycosylation | ||||
Reactome | O-linked glycosylation of mucins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
O-linked glycosylation | ||||
O-linked glycosylation of mucins | ||||
Post-translational protein modification | ||||
Gene Ontology Terms (16)
Functions (6)
Components (5)
Processes (5)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (51)
1 – 10 of 51
C1GALT1
Family: Enzyme
Novelty: 0.01514342
Score: 0.965
Data Source: STRINGDB
GCNT1
Family: Enzyme
Novelty: 0.0114317
Score: 0.961
Data Source: STRINGDB
C1GALT1C1
Family: Enzyme
Novelty: 0.00694171
Score: 0.957
Data Source: STRINGDB
GCNT3
Family: Enzyme
Novelty: 0.04293454
Score: 0.955
Data Source: STRINGDB
ST6GALNAC1
Family: Enzyme
Novelty: 0.00846998
Score: 0.949
Data Source: STRINGDB
MUC20
Novelty: 0.07155729
Score: 0.94
Data Source: STRINGDB
MUC1
Novelty: 0.00029046
Score: 0.926
Data Source: STRINGDB
MUC5B
Novelty: 0.00088548
Score: 0.922
Data Source: STRINGDB
MUC6
Novelty: 0.00438241
Score: 0.921
Data Source: STRINGDB
MUC4
Novelty: 0.00238494
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score 5.88
PubMed score by year
PubTator Score 6.53
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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