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Tbio
SLC36A4
Proton-coupled amino acid transporter 4

Protein Summary
Description
Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine. SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326402
  • ENSP00000317382
  • ENSG00000180773
  • ENST00000529184
  • ENSP00000436570

Symbol
  • PAT4
  • PAT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cell line
0.58
transcription factor binding site profile
0.56
tissue sample
0.53
cellular component
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.25   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.25   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (37)
1 – 10 of 37
RAB12
Tbio
Family:  Enzyme
Novelty:  0.05361391
Score:  0.655
Data Source:  STRINGDB
SLC38A9
Tbio
Family:  Transporter
Novelty:  0.0879703
Score:  0.637
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.617
Data Source:  STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
Score:  0.603
Data Source:  STRINGDB
RAB1A
Tbio
Family:  Enzyme
Novelty:  0.00307527
Score:  0.599
Data Source:  STRINGDB
LIMS1
Tbio
Novelty:  0.00648304
Score:  0.575
Data Source:  STRINGDB
RPS6KB1
Tchem
Family:  Kinase
Novelty:  0.00044681
Score:  0.558
Data Source:  STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
Score:  0.552
Data Source:  STRINGDB
SLC38A2
Tbio
Family:  Transporter
Novelty:  0.00808235
Score:  0.548
Data Source:  STRINGDB
SLC38A7
Tdark
Family:  Transporter
Novelty:  0.24353276
Score:  0.543
Data Source:  STRINGDB
Pathways (8)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Metabolism
Metabolism of amino acids and derivatives
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
WormBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
24.5
1
1
0
1
5.2
response to radiation
1
1
0
3.1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
24.5
0
1
5.2
response to radiation
0
3.1
0.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 36 member 4
VGNC:7748
466748
Mouse
MGI:2442595
234967
Rat
RGD:1311528
315439
Dog
solute carrier family 36 member 4
VGNC:46385
607790
Horse
solute carrier family 36 member 4
VGNC:23183
100059092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 36 member 4
Mouse
Rat
Dog
solute carrier family 36 member 4
Horse
solute carrier family 36 member 4
Publication Statistics
PubMed Score 36.25
PubMed score by year
PubTator Score 7.71
PubTator score by year