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Tchem
GIGYF2
GRB10-interacting GYF protein 2

Protein Summary
Description
Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373563
  • ENSP00000362664
  • ENSG00000204120
  • ENST00000409196
  • ENSP00000387070
  • ENST00000409451
  • ENSP00000387170
  • ENST00000409547
  • ENSP00000386537

Symbol
  • KIAA0642
  • PERQ2
  • TNRC15
  • GYF2
  • PERQ2
  • PERQ3
  • PARK11
  • TNRC15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
ligand (protein) perturbation
0.96
interacting protein
0.86
kinase perturbation
0.81
protein complex
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.7   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.7   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2337520
Rendered image for CHEMBL2337520
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
4
3
2.9
96.9
mathematical ability
4
4
7
94.4
self reported educational attainment
3
3
4
90.7
aspartate aminotransferase measurement
3
3
2
10
90.4
heel bone mineral density
3
2
3
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
2.9
96.9
mathematical ability
7
94.4
self reported educational attainment
4
90.7
aspartate aminotransferase measurement
2
10
90.4
heel bone mineral density
3
89.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRB10 interacting GYF protein 2
VGNC:440
460017
Macaque
GRB10 interacting GYF protein 2
713675
Mouse
MGI:2138584
227331
Dog
GRB10 interacting GYF protein 2
VGNC:41214
612838
Horse
GRB10 interacting GYF protein 2
VGNC:18339
100064814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRB10 interacting GYF protein 2
Macaque
GRB10 interacting GYF protein 2
Mouse
Dog
GRB10 interacting GYF protein 2
Horse
GRB10 interacting GYF protein 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6Y7W6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (27)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (83)
1 – 10 of 83
EIF4E2
Tbio
Novelty:  0.0490219
p_int:  0.99999999
p_ni:  1e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999416275
p_ni:  0.000583724
Data Source:  BioPlex
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.984086086
p_ni:  0.015913914
Data Source:  BioPlex
C10orf88
Tdark
Novelty:  0.49807003
p_int:  0.969155191
p_ni:  0.030844807
p_wrong:  1e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.801673472
p_ni:  0.198326219
p_wrong:  3.09e-7
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.773154944
p_ni:  0.22684505
p_wrong:  6e-9
Data Source:  BioPlex
GRB10
Tbio
Novelty:  0.00762794
Score:  0.934
Data Source:  STRINGDB
DIS3L
Tbio
Family:  Enzyme
Novelty:  0.12886408
Score:  0.822
Data Source:  STRINGDB
ZNF598
Tbio
Novelty:  0.10104457
Score:  0.813
Data Source:  STRINGDB
CNOT9
Tbio
Novelty:  0.05592835
Score:  0.776
Data Source:  STRINGDB
Publication Statistics
PubMed Score  46.70

PubMed score by year
PubTator Score  34.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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