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Tbio
HACD2
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

Protein Summary
Description
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383657
  • ENSP00000373153
  • ENSG00000206527

Symbol
  • PTPLB
  • PTPLB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
kinase perturbation
0.95
histone modification site profile
0.87
transcription factor binding site profile
0.85
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
70.4
sleep duration
1
1
1
48.4
electrocardiography
1
1
4
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
70.4
sleep duration
1
48.4
electrocardiography
4
11.6
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3-hydroxyacyl-CoA dehydratase 2
VGNC:7064
746499
Macaque
3-hydroxyacyl-CoA dehydratase 2
715374
Mouse
MGI:1918007
70757
Dog
3-hydroxyacyl-CoA dehydratase 2
VGNC:53075
608764
Horse
3-hydroxyacyl-CoA dehydratase 2
VGNC:18678
100070489
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3-hydroxyacyl-CoA dehydratase 2
Macaque
3-hydroxyacyl-CoA dehydratase 2
Mouse
Dog
3-hydroxyacyl-CoA dehydratase 2
Horse
3-hydroxyacyl-CoA dehydratase 2
Pathways (10)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Gene Ontology Terms (15)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (55)
1 – 10 of 55
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
p_int: 0.998535049
p_ni: 0.001464951
Data Source: BioPlex
B4GAT1
Tbio
Family: Enzyme
Novelty: 0.14959923
p_int: 0.991555983
p_ni: 0.008444017
p_wrong: 1e-9
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.983775235
p_ni: 0.016224765
Score: 0.293
Data Source: BioPlex,STRINGDB
SLC2A12
Tbio
Family: Transporter
Novelty: 0.01455533
p_int: 0.966672544
p_ni: 0.033327433
p_wrong: 2.2e-8
Data Source: BioPlex
SLC6A15
Tchem
Family: Transporter
Novelty: 0.04011524
p_int: 0.961883804
p_ni: 0.03811618
p_wrong: 1.6e-8
Score: 0.18
Data Source: BioPlex,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
p_int: 0.956721518
p_ni: 0.041794419
p_wrong: 0.001484063
Score: 0.151
Data Source: BioPlex,STRINGDB
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.946770286
p_ni: 0.053229712
p_wrong: 2e-9
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.944860419
p_ni: 0.05511879
p_wrong: 0.000020791
Data Source: BioPlex
SLC1A1
Tchem
Family: Transporter
Novelty: 0.00218479
p_int: 0.941953682
p_ni: 0.058023116
p_wrong: 0.000023202
Data Source: BioPlex
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.940479331
p_ni: 0.059520669
Data Source: BioPlex
Publication Statistics
PubMed Score  4.38

PubMed score by year
PubTator Score  2.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer