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Tbio
DNMBP
Dynamin-binding protein

Protein Summary
Description
Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). This gene encodes a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324109
  • ENSP00000315659
  • ENSG00000107554

Symbol
  • KIAA1010
  • TUBA
  • ARHGEF36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.8
interacting protein
0.72
tissue sample
0.72
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.99   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.99   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (58)
1 – 10 of 58
DNM2
Tchem
Novelty:  0.00265965
p_int:  0.999848614
p_ni:  0.000151222
p_wrong:  1.64e-7
Score:  0.556
Data Source:  BioPlex,STRINGDB
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.999789089
p_ni:  0.000210906
p_wrong:  5e-9
Score:  0.525
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.949
Data Source:  STRINGDB
ZNF768
Tdark
Family:  TF
Novelty:  1.10291698
Score:  0.739
Data Source:  STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.724
Data Source:  STRINGDB
DNM1
Tbio
Novelty:  0.00319082
Score:  0.695
Data Source:  STRINGDB
WIPF2
Tbio
Novelty:  0.11973409
Score:  0.688
Data Source:  STRINGDB
RAPGEF1
Tbio
Novelty:  0.00365765
Score:  0.667
Data Source:  STRINGDB
VTA1
Tbio
Novelty:  0.01697854
Score:  0.663
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.652
Data Source:  STRINGDB
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
4
4
96.7
interleukin-27 measurement
1
1
1
87.3
bilirubin measurement
1
2
2
70.4
creatine kinase measurement
2
1
2
67.8
body height
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
96.7
interleukin-27 measurement
1
87.3
bilirubin measurement
2
70.4
creatine kinase measurement
2
67.8
body height
1
58.4
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dynamin binding protein
709334
Mouse
MGI:1917352
71972
Rat
RGD:1583840
309362
Dog
dynamin binding protein
VGNC:40035
477794
Horse
dynamin binding protein
VGNC:17254
100060622
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dynamin binding protein
Mouse
Rat
Dog
dynamin binding protein
Horse
dynamin binding protein
Publication Statistics
PubMed Score 14.99
PubMed score by year
PubTator Score 58.13
PubTator score by year