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Tchem
NAPRT
Nicotinate phosphoribosyltransferase

Protein Summary
Description
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426292
  • ENSP00000390949
  • ENSG00000147813
  • ENST00000449291
  • ENSP00000401508
  • ENST00000621955
  • ENSP00000480017
  • ENSG00000278488
  • ENST00000632139
  • ENSP00000488794

Symbol
  • FHIP
  • NAPRT1
  • NAPRT1
  • PP3856
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
pathway
0.8
tissue sample
0.58
transcription factor binding site profile
0.58
cell type or tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.21   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.21   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (12)
indomethacin
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flufenamic acid
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mefenamic acid
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acetylsalicylic acid
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oxyphenbutazone
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phenylbutazone
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sulfinpyrazone
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salicylic acid
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phenazone
Rendered image for phenazone
acetanilide
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Active Ligands (10)
3-Pyridylacetic acid
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2-Pyrazinoic acid
Rendered image for 2-Pyrazinoic acid
2-Hydroxynicotinic acid
Rendered image for 2-Hydroxynicotinic acid
2-Fluoronicotinic acid
Rendered image for 2-Fluoronicotinic acid
6-Chloronicotinic acid
Rendered image for 6-Chloronicotinic acid
3-Pyridylsulfonic acid
Rendered image for 3-Pyridylsulfonic acid
Isonicotinic acid
Rendered image for Isonicotinic acid
Pyridine
Rendered image for Pyridine
2-Amino-nicotinic acid
Rendered image for 2-Amino-nicotinic acid
Picolinic acid
Rendered image for Picolinic acid
Protein-Protein Interactions (165)
ETNK1
Tbio
Family:  Kinase
Novelty:  0.04817798
p_int:  0.933196167
p_ni:  0.064562227
p_wrong:  0.002241606
Score:  0.27
Data Source:  BioPlex,STRINGDB
LNPEP
Tchem
Family:  Enzyme
Novelty:  0.00249049
p_int:  0.847117665
p_ni:  0.152882335
Score:  0.258
Data Source:  BioPlex,STRINGDB
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
Score:  0.986
Data Source:  STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.98
Data Source:  STRINGDB
NMRK1
Tbio
Family:  Kinase
Novelty:  0.04761376
Score:  0.977
Data Source:  STRINGDB
NMNAT3
Tbio
Family:  Enzyme
Novelty:  0.03261313
Score:  0.973
Data Source:  STRINGDB
NMNAT2
Tbio
Family:  Enzyme
Novelty:  0.01709189
Score:  0.972
Data Source:  STRINGDB
NMRK2
Tbio
Family:  Kinase
Novelty:  0.11112212
Score:  0.963
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.958
Data Source:  STRINGDB
ACLY
Tclin
Family:  Enzyme
Novelty:  0.00114812
Score:  0.941
Data Source:  STRINGDB
Pathways (19)
Immune System (R-HSA-168256)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
92.3
red blood cell distribution width
3
2
3
92.3
metabolite measurement
1
1
1
82.8
metabolite measurement
1
1
1
82.8
C-reactive protein measurement
2
2
2
75.9
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
92.3
red blood cell distribution width
3
92.3
metabolite measurement
1
82.8
metabolite measurement
1
82.8
C-reactive protein measurement
2
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nicotinate phosphoribosyltransferase
VGNC:13191
739858
Macaque
nicotinate phosphoribosyltransferase
708992
Mouse
MGI:2442664
223646
Rat
RGD:1302945
315085
Dog
nicotinate phosphoribosyltransferase
VGNC:43623
609412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nicotinate phosphoribosyltransferase
Macaque
nicotinate phosphoribosyltransferase
Mouse
Rat
Dog
nicotinate phosphoribosyltransferase
Publication Statistics
PubMed Score 31.21
PubMed score by year
PubTator Score 30.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title