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Tbio
NAPRT
Nicotinate phosphoribosyltransferase

Protein Summary
Description
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426292
  • ENSP00000390949
  • ENSG00000147813
  • ENST00000449291
  • ENSP00000401508
  • ENST00000621955
  • ENSP00000480017
  • ENSG00000278488
  • ENST00000632139
  • ENSP00000488794

Symbol
  • FHIP
  • NAPRT1
  • NAPRT1
  • PP3856
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
pathway
0.8
tissue sample
0.58
transcription factor binding site profile
0.58
cell type or tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.64   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.64   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Protein-Protein Interactions (165)
1 – 10 of 165
ETNK1
Tbio
Family: Kinase
Novelty: 0.04817798
p_int: 0.933196167
p_ni: 0.064562227
p_wrong: 0.002241606
Score: 0.27
Data Source: BioPlex,STRINGDB
LNPEP
Tchem
Family: Enzyme
Novelty: 0.00249049
p_int: 0.847117665
p_ni: 0.152882335
Score: 0.258
Data Source: BioPlex,STRINGDB
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
Score: 0.986
Data Source: STRINGDB
NMNAT1
Tbio
Family: Enzyme
Novelty: 0.01110899
Score: 0.98
Data Source: STRINGDB
NMRK1
Tbio
Family: Kinase
Novelty: 0.04761376
Score: 0.977
Data Source: STRINGDB
NMNAT3
Tbio
Family: Enzyme
Novelty: 0.03261313
Score: 0.973
Data Source: STRINGDB
NMNAT2
Tbio
Family: Enzyme
Novelty: 0.01709189
Score: 0.972
Data Source: STRINGDB
NMRK2
Tbio
Family: Kinase
Novelty: 0.11112212
Score: 0.963
Data Source: STRINGDB
PNP
Tclin
Family: Enzyme
Novelty: 0.0019084
Score: 0.958
Data Source: STRINGDB
ACLY
Tclin
Family: Enzyme
Novelty: 0.00114812
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.64

PubMed score by year
PubTator Score  30.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer