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Tbio
NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

Protein Summary
Description
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265663
  • ENSP00000265663
  • ENSG00000165802
  • ENST00000371472
  • ENSP00000360527
  • ENST00000371473
  • ENSP00000360528
  • ENST00000371474
  • ENSP00000360529
  • ENST00000371475
  • ENSP00000360530
  • ENST00000437259
  • ENSP00000412007

Symbol
  • NELF
  • HH9
  • NELF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.86
transcription factor perturbation
0.74
biological process
0.71
tissue sample
0.71
cell type or tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.2   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.2   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
2
3
1.1
90.8
mathematical ability
4
2
4
85.2
self reported educational attainment
1
1
1
72.6
insomnia measurement
1
1
0
1.1
62.8
cognitive function measurement
1
1
1
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
90.8
mathematical ability
4
85.2
self reported educational attainment
1
72.6
insomnia measurement
0
1.1
62.8
cognitive function measurement
1
60.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NMDA receptor synaptonuclear signaling and neuronal migration factor
VGNC:4811
104008067
Macaque
NMDA receptor synaptonuclear signaling and neuronal migration factor
704312
Mouse
MGI:1861755
56876
Rat
RGD:619819
117536
Horse
NMDA receptor synaptonuclear signaling and neuronal migration factor
VGNC:20908
100147094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NMDA receptor synaptonuclear signaling and neuronal migration factor
Macaque
NMDA receptor synaptonuclear signaling and neuronal migration factor
Mouse
Rat
Horse
NMDA receptor synaptonuclear signaling and neuronal migration factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6X4W1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (26)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (21)
1 – 10 of 21
KCTD15
Tbio
Novelty:  0.05277304
p_int:  0.999993776
p_ni:  0.000006224
Score:  0.352
Data Source:  BioPlex,STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
p_int:  0.999841019
p_ni:  0.00015898
p_wrong:  1e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.961983561
p_ni:  0.038016439
Score:  0.209
Data Source:  BioPlex,STRINGDB
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.778663726
p_ni:  0.010231474
p_wrong:  0.211104799
Score:  0.19
Data Source:  BioPlex,STRINGDB
PROKR2
Tchem
Family:  GPCR
Novelty:  0.01400881
Score:  0.674
Data Source:  STRINGDB
ANOS1
Tbio
Novelty:  0.00254765
Score:  0.669
Data Source:  STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.655
Data Source:  STRINGDB
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
Score:  0.65
Data Source:  STRINGDB
PROK2
Tbio
Novelty:  0.00512397
Score:  0.627
Data Source:  STRINGDB
TAC3
Tchem
Novelty:  0.001685
Score:  0.625
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.20

PubMed score by year
PubTator Score  62.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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