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Tdark
HEPN1
Putative cancer susceptibility gene HEPN1 protein

Protein Summary
Description
This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354). [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000408930
  • ENSP00000386143
  • ENSG00000221932
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.47
microRNA
0.38
biological term
0.34
tissue sample
0.34
cell line
0.29


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (17)
1 – 10 of 17
ANXA5
Tbio
Novelty: 0.00007584
Score: 0.9
Data Source: STRINGDB
MT3
Tbio
Novelty: 0.00321947
Score: 0.524
Data Source: STRINGDB
OPALIN
Tdark
Novelty: 0.08221612
Score: 0.522
Data Source: STRINGDB
NTSR2
Tchem
Family: GPCR
Novelty: 0.00699381
Score: 0.522
Data Source: STRINGDB
MAG
Tchem
Novelty: 0.00085621
Score: 0.52
Data Source: STRINGDB
TMEM235
Tdark
Novelty: 0.92307692
Score: 0.513
Data Source: STRINGDB
SLC6A1
Tclin
Family: Transporter
Novelty: 0.00165116
Score: 0.512
Data Source: STRINGDB
AQP4
Tbio
Novelty: 0.00031632
Score: 0.483
Data Source: STRINGDB
PMP2
Tbio
Novelty: 0.00428146
Score: 0.475
Data Source: STRINGDB
KCNJ9
Tbio
Family: IC
Novelty: 0.02279401
Score: 0.474
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.01

PubMed score by year
PubTator Score  3.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer