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Tbio
CHRDL2
Chordin-like protein 2

Protein Summary
Description
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263671
  • ENSP00000263671
  • ENSG00000054938
  • ENST00000376332
  • ENSP00000365510
  • ENST00000528471
  • ENSP00000434589
  • ENST00000534276
  • ENSP00000432055

Symbol
  • BNF1
  • CHL2
  • BNF1
  • CHL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.6
cell line
0.59
PubMedID
0.58
tissue
0.52
histone modification site profile
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
0
1.1
90
1
1
0
1.2
70.5
grip strength measurement
3
2
3
60.9
spine bone size
1
1
1
49.5
electrocardiography
1
1
8
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90
0
1.2
70.5
grip strength measurement
3
60.9
spine bone size
1
49.5
electrocardiography
8
45.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chordin like 2
VGNC:11755
466898
Macaque
chordin like 2
693657
Mouse
MGI:1916371
69121
Rat
RGD:1306179
308854
Dog
chordin like 2
VGNC:39230
609312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chordin like 2
Macaque
chordin like 2
Mouse
Rat
Dog
chordin like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6WN34-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (32)
1 – 10 of 32
BMP2
Tbio
Novelty:  0.00016974
Score:  0.912
Data Source:  STRINGDB
LVRN
Tbio
Family:  Enzyme
Novelty:  0.05879608
Score:  0.757
Data Source:  STRINGDB
TWSG1
Tbio
Novelty:  0.00255544
Score:  0.72
Data Source:  STRINGDB
BMP5
Tbio
Novelty:  0.00866987
Score:  0.717
Data Source:  STRINGDB
FSTL5
Tbio
Novelty:  0.09979909
Score:  0.703
Data Source:  STRINGDB
BMP6
Tbio
Novelty:  0.00197133
Score:  0.664
Data Source:  STRINGDB
XRRA1
Tdark
Novelty:  0.80740801
Score:  0.66
Data Source:  STRINGDB
SOSTDC1
Tbio
Novelty:  0.02140914
Score:  0.651
Data Source:  STRINGDB
SOST
Tclin
Novelty:  0.0009273
Score:  0.648
Data Source:  STRINGDB
GDF5
Tbio
Novelty:  0.00218118
Score:  0.644
Data Source:  STRINGDB
Publication Statistics
PubMed Score  52.80

PubMed score by year
PubTator Score  17.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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