MPRIP
Myosin phosphatase Rho-interacting protein
Protein Summary
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
- ENST00000341712
- ENSP00000342379
- ENSG00000133030
- ENST00000395811
- ENSP00000379156
- KIAA0864
- MRIP
- RHOIP3
- MRIP
- RIP3
- M-RIP
- RHOIP3
- p116Rip
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
disease perturbation | 0.96 | ||
ligand (protein) perturbation | 0.83 | ||
virus perturbation | 0.79 | ||
microRNA | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.82 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 191 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.82 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 191 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0