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Tbio
MPRIP
Myosin phosphatase Rho-interacting protein

Protein Summary
Description
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341712
  • ENSP00000342379
  • ENSG00000133030
  • ENST00000395811
  • ENSP00000379156

Symbol
  • KIAA0864
  • MRIP
  • RHOIP3
  • MRIP
  • RIP3
  • M-RIP
  • RHOIP3
  • p116Rip
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.96
ligand (protein) perturbation
0.83
virus perturbation
0.79
microRNA
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.78   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.78   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999788
p_ni:  2.12e-7
Data Source:  BioPlex
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999993685
p_ni:  0.000006315
Data Source:  BioPlex
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.999993099
p_ni:  0.000006901
Data Source:  BioPlex
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999992967
p_ni:  0.000007033
Data Source:  BioPlex
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.999992321
p_ni:  0.000007655
p_wrong:  2.4e-8
Data Source:  BioPlex
PACSIN1
Tbio
Family:  Enzyme
Novelty:  0.01482925
p_int:  0.999987679
p_ni:  0.000012321
Score:  0.663
Data Source:  BioPlex,STRINGDB
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.999976137
p_ni:  0.000023855
p_wrong:  7e-9
Data Source:  BioPlex
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.999969667
p_ni:  0.000030333
p_wrong:  1e-9
Data Source:  BioPlex
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.99984956
p_ni:  0.00015044
Data Source:  BioPlex
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.999794301
p_ni:  0.000205699
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
3
8
10
99.6
blood protein measurement
2
6
6
99.1
albumin:globulin ratio measurement
2
3
3
97.8
mean platelet volume
3
3
4
87.6
monocyte count
2
1
2
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
10
99.6
blood protein measurement
6
99.1
albumin:globulin ratio measurement
3
97.8
mean platelet volume
4
87.6
monocyte count
2
87
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
myosin phosphatase Rho interacting protein
100427935
Mouse
MGI:1349438
26936
Rat
RGD:619947
116504
Dog
myosin phosphatase Rho interacting protein
VGNC:54331
479530
Cow
myosin phosphatase Rho interacting protein
533979
Species
Name
OMA
EggNOG
Inparanoid
Macaque
myosin phosphatase Rho interacting protein
Mouse
Rat
Dog
myosin phosphatase Rho interacting protein
Cow
myosin phosphatase Rho interacting protein
Publication Statistics
PubMed Score 31.78
PubMed score by year
PubTator Score 15.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title