Tchem NPSR1 Neuropeptide S receptor

Protein Summary

Description

G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases. This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q6W5P4
• A2RTZ4
• Q2XP58
• Q56H76
• Q56H77
• Q56H78
• Q6JSL4
• Q6JSL5
• Q6JSL6
• Q6JSL7
• Q6JSL8
• Q6W5P3
• Q6ZMB8

Gene Name

• NPSR1

Ensembl ID

• ENST00000359791
• ENSP00000352839
• ENSG00000187258
• ENST00000360581
• ENSP00000353788
• ENST00000381539
• ENSP00000370950
• ENST00000381542
• ENSP00000370953
• ENST00000381544
• ENSP00000370955
• ENST00000381553
• ENSP00000370965
• ENST00000396095
• ENSP00000379402
• ENST00000465305
• ENSP00000434955
• ENST00000531252
• ENSP00000433258

Symbol

• GPR154
• GPRA
• PGR14
• GPRA
• NPSR
• VRR1
• ASRT2
• PGR14
• GPR154

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.66
protein domain	0.58
phenotype	0.54
tissue	0.54
disease	0.51

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Neuropeptide S Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Neuropeptide S Receptor / Neuropeptide S Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.86   (req: < 5)

Gene RIFs: 83   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.86   (req: >= 5)

Gene RIFs: 83   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0