Tchem NPSR1 Neuropeptide S receptor

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Neuropeptide S Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Neuropeptide S Receptor / Neuropeptide S Receptor

Protein Summary

Description

G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases. This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q6W5P4
• A2RTZ4
• Q2XP58
• Q56H76
• Q56H77
• Q56H78
• Q6JSL4
• Q6JSL5
• Q6JSL6
• Q6JSL7
• Q6JSL8
• Q6W5P3
• Q6ZMB8

Gene Name

• NPSR1

Ensembl ID

• ENST00000359791
• ENSP00000352839
• ENSG00000187258
• ENST00000360581
• ENSP00000353788
• ENST00000381539
• ENSP00000370950
• ENST00000381542
• ENSP00000370953
• ENST00000381544
• ENSP00000370955
• ENST00000381553
• ENSP00000370965
• ENST00000396095
• ENSP00000379402
• ENST00000465305
• ENSP00000434955
• ENST00000531252
• ENSP00000433258

Symbol

• GPR154
• GPRA
• PGR14
• GPRA
• NPSR
• VRR1
• ASRT2
• PGR14
• GPR154

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.66
protein domain	0.58
phenotype	0.54
tissue	0.54
disease	0.51

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.15   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.15   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (40)

Explore Active Ligands

1 – 10 of 40

NCGC 84

NPSR1Tchem GPCR

IC50 : 9.02

PI1

NPSR1Tchem GPCR

IC50 : 7.37

QA1

NPSR1Tchem GPCR

IC50 : 8.92

SHA 68

NPSR1Tchem GPCR

IC50 : 8.28

CHEMBL469696

NPSR1Tchem GPCR

IC50 : 8.7

CHEMBL3086823

NPSR1Tchem GPCR

IC50 : 8.66

CHEMBL3086836

NPSR1Tchem GPCR

IC50 : 8.49

CHEMBL3086821

NPSR1Tchem GPCR

IC50 : 8.47

CHEMBL3086837

NPSR1Tchem GPCR

IC50 : 8.47

CHEMBL3086824

NPSR1Tchem GPCR

IC50 : 8.35

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
exercise	EFO_0000483	1	1	1		4.2

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
exercise	EFO_0000483	1		4.2

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neuropeptide S receptor 1	VGNC:4446	747277
Macaque	neuropeptide S receptor 1		574355
Mouse	neuropeptide S receptor 1	MGI:2441738	319239
Rat	neuropeptide S receptor 1	RGD:1564154	300458
Dog	neuropeptide S receptor 1	VGNC:54789	482394

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neuropeptide S receptor 1
Macaque	neuropeptide S receptor 1
Mouse	neuropeptide S receptor 1
Rat	neuropeptide S receptor 1
Dog	neuropeptide S receptor 1

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

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AF-Q6W5P4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)

Reactome (8)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (q) signalling events	219 targets	R-HSA-416476
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Gene Ontology Terms (8)

Functions (2)

Components (3)

Processes (3)

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1 – 2 of 2

GO Term	Evidence	Assigned by
neuropeptide receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
vasopressin receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (551)

Explore Interacting Targets

1 – 10 of 551

• See Interactions on String-DB

NPS

Tbio

Novelty:  0.00692108

Score:  0.982

Data Source:  Reactome,STRINGDB

CASR

Tclin

Family:  GPCR

Novelty:  0.00061316

Score:  0.967

Data Source:  STRINGDB

NTS

Tbio

Novelty:  0.00033201

Score:  0.96

Data Source:  STRINGDB

FAU

Tbio

Novelty:  0.01170009

Score:  0.959

Data Source:  STRINGDB

FAU

Tbio

Novelty:  0.01170009

Score:  0.959

Data Source:  STRINGDB

TAC1

Tbio

Novelty:  0.00006575

Score:  0.958

Data Source:  STRINGDB

CRHR1

Tclin

Family:  GPCR

Novelty:  0.00101773

Score:  0.956

Data Source:  STRINGDB

CALCA

Tbio

Novelty:  0.00010496

Score:  0.953

Data Source:  STRINGDB

CALCA

Tclin

Novelty:  0.00010496

Score:  0.953

Data Source:  STRINGDB

PTH

Tbio

Novelty:  0.00003263

Score:  0.951

Data Source:  STRINGDB

Publication Statistics

PubMed Score  240.15

PubMed score by year

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PubTator Score  96.18

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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ProtVista Viewer

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Asthma
Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
exercise

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
respiratory system phenotype