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Tchem
NPSR1
Neuropeptide S receptor

Protein Summary
Description
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases. This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359791
  • ENSP00000352839
  • ENSG00000187258
  • ENST00000360581
  • ENSP00000353788
  • ENST00000381539
  • ENSP00000370950
  • ENST00000381542
  • ENSP00000370953
  • ENST00000381544
  • ENSP00000370955
  • ENST00000381553
  • ENSP00000370965
  • ENST00000396095
  • ENSP00000379402
  • ENST00000465305
  • ENSP00000434955
  • ENST00000531252
  • ENSP00000433258

Symbol
  • GPR154
  • GPRA
  • PGR14
  • GPRA
  • NPSR
  • VRR1
  • ASRT2
  • PGR14
  • GPR154
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.66
protein domain
0.58
phenotype
0.54
tissue
0.54
disease
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.15   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.15   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
exercise
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
exercise
1
4.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide S receptor 1
VGNC:4446
747277
Macaque
neuropeptide S receptor 1
574355
Mouse
MGI:2441738
319239
Rat
RGD:1564154
300458
Dog
neuropeptide S receptor 1
VGNC:54789
482394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide S receptor 1
Macaque
neuropeptide S receptor 1
Mouse
Rat
Dog
neuropeptide S receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6W5P4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (551)
1 – 10 of 551
NPS
Tbio
Novelty:  0.00692108
Score:  0.982
Data Source:  Reactome,STRINGDB
CASR
Tclin
Family:  GPCR
Novelty:  0.00061316
Score:  0.967
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.96
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.959
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.959
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.958
Data Source:  STRINGDB
CRHR1
Tclin
Family:  GPCR
Novelty:  0.00101773
Score:  0.956
Data Source:  STRINGDB
CALCA
Tbio
Novelty:  0.00010496
Score:  0.953
Data Source:  STRINGDB
CALCA
Tclin
Novelty:  0.00010496
Score:  0.953
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.951
Data Source:  STRINGDB
Publication Statistics
PubMed Score  240.15

PubMed score by year
PubTator Score  96.18

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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