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Tbio
MUC6
Mucin-6

Protein Summary
Description
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421673
  • ENSP00000406861
  • ENSG00000184956
  • ENST00000636545
  • ENSP00000490759
  • ENSG00000283350

Symbol
  • MUC-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell line
0.68
cell type or tissue
0.59
biological term
0.55
cellular component
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.24   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.24   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
81.1
1
1
0
1.5
81.1
3
2
0
1.1
64.3
3
2
0
1.1
64.3
eosinophil count
1
1
1
9.1
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
81.1
0
1.5
81.1
0
1.1
64.3
0
1.1
64.3
eosinophil count
1
9.1
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2663233
353328
Rat
RGD:628826
282586
Dog
mucin 6, oligomeric mucus/gel-forming
100855904
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mucin 6, oligomeric mucus/gel-forming
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6W4X9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (41)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Reactome
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Reactome
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (101)
1 – 10 of 101
MUC1
Tchem
Novelty:  0.00024203
Score:  0.985
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.984
Data Source:  STRINGDB
MUC7
Tbio
Novelty:  0.00750654
Score:  0.978
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.974
Data Source:  STRINGDB
MUC17
Tbio
Novelty:  0.03624836
Score:  0.972
Data Source:  STRINGDB
MUC12
Tbio
Novelty:  0.04323645
Score:  0.972
Data Source:  STRINGDB
MUC13
Tbio
Novelty:  0.01282861
Score:  0.971
Data Source:  STRINGDB
MUC20
Tbio
Novelty:  0.04645313
Score:  0.97
Data Source:  STRINGDB
MUC3A
Tbio
Novelty:  0.0576775
Score:  0.969
Data Source:  STRINGDB
MUC15
Tbio
Novelty:  0.02213624
Score:  0.967
Data Source:  STRINGDB
Publication Statistics
PubMed Score  318.24

PubMed score by year
PubTator Score  197.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer