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Tbio
BCOR
BCL-6 corepressor

Protein Summary
Description
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342274
  • ENSP00000345923
  • ENSG00000183337
  • ENST00000378444
  • ENSP00000367705
  • ENST00000378455
  • ENSP00000367716
  • ENST00000397354
  • ENSP00000380512

Symbol
  • KIAA1575
  • MAA2
  • ANOP2
  • MCOPS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
biological process
0.9
virus perturbation
0.85
transcription factor binding site profile
0.82
transcription factor
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.74   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.74   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999990756
p_ni:  0.000009244
Score:  0.585
Data Source:  BioPlex,STRINGDB
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.99998559
p_ni:  0.00001441
Score:  0.683
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999981068
p_ni:  0.000018932
Score:  0.808
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999566388
p_ni:  0.000433612
Data Source:  BioPlex
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.998673483
p_ni:  0.001326516
Score:  0.464
Data Source:  BioPlex,STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.998665634
p_ni:  0.001334366
Data Source:  BioPlex
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.997021099
p_ni:  0.002978888
p_wrong:  1.4e-8
Data Source:  BioPlex
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.995031145
p_ni:  0.004968855
Score:  0.286
Data Source:  BioPlex,STRINGDB
DCAF15
Tdark
Novelty:  0.13476661
p_int:  0.993081126
p_ni:  0.006918873
Data Source:  BioPlex
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.988381408
p_ni:  0.011618591
Score:  0.204
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL6 corepressor
VGNC:12226
465574
Macaque
BCL6 corepressor
698644
Mouse
MGI:1918708
71458
Rat
RGD:1562735
317346
Dog
BCL6 corepressor
VGNC:53706
480880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL6 corepressor
Macaque
BCL6 corepressor
Mouse
Rat
Dog
BCL6 corepressor
Publication Statistics
PubMed Score 16.74
PubMed score by year
PubTator Score 103.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title