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Tbio
PACS1
Phosphofurin acidic cluster sorting protein 1

Protein Summary
Description
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.84
cellular component
0.73
small molecule perturbation
0.73
cell type or tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.21   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.21   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
WDR37
Tbio
Novelty:  0.1677975
p_int:  0.999999966
p_ni:  2.1e-8
p_wrong:  1.2e-8
Score:  0.888
Data Source:  BioPlex,STRINGDB
LEAP2
Tbio
Novelty:  0.01484908
p_int:  0.99999833
p_ni:  0.000001668
p_wrong:  2e-9
Data Source:  BioPlex
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.999995609
p_ni:  0.000001821
p_wrong:  0.00000257
Score:  0.795
Data Source:  BioPlex,STRINGDB
SNX24
Tdark
Novelty:  0.20838126
p_int:  0.999921071
p_ni:  0.000062163
p_wrong:  0.000016766
Score:  0.266
Data Source:  BioPlex,STRINGDB
FGFR1OP
Tbio
Novelty:  0.09922864
Score:  0.89
Data Source:  STRINGDB
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
Score:  0.858
Data Source:  STRINGDB
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
Score:  0.831
Data Source:  STRINGDB
BCAP31
Tbio
Novelty:  0.01363316
Score:  0.779
Data Source:  STRINGDB
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
Score:  0.771
Data Source:  STRINGDB
S100B
Tchem
Novelty:  0.00031007
Score:  0.72
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Infectious disease
Reactome
Nef mediated downregulation of MHC class I complex cell surface expression
Name
Explore in Pharos
Explore in Source
Disease
HIV Infection
Host Interactions of HIV factors
Infectious disease
Nef mediated downregulation of MHC class I complex cell surface expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
3
4
82.9
BMI-adjusted waist circumference
1
4
4
81.1
uric acid measurement
1
1
1
72.9
mathematical ability
2
3
3
71.6
C-reactive protein measurement
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
82.9
BMI-adjusted waist circumference
4
81.1
uric acid measurement
1
72.9
mathematical ability
3
71.6
C-reactive protein measurement
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphofurin acidic cluster sorting protein 1
VGNC:3078
466669
Macaque
phosphofurin acidic cluster sorting protein 1
714696
Mouse
MGI:1277113
107975
Rat
RGD:620579
171444
Dog
phosphofurin acidic cluster sorting protein 1
VGNC:44229
483716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphofurin acidic cluster sorting protein 1
Macaque
phosphofurin acidic cluster sorting protein 1
Mouse
Rat
Dog
phosphofurin acidic cluster sorting protein 1
Publication Statistics
PubMed Score 58.21
PubMed score by year
PubTator Score 31.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title