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Tbio
TFAP2E
Transcription factor AP-2-epsilon

Protein Summary
Description
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373235
  • ENSP00000362332
  • ENSG00000116819

Symbol
  • AP2E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
gene perturbation
0.68
histone modification site profile
0.64
tissue sample
0.62
biological process
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
31.4
mean corpuscular volume
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
31.4
mean corpuscular volume
1
11.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-2 epsilon
VGNC:14284
469276
Macaque
transcription factor AP-2 epsilon
100428085
Mouse
MGI:2679630
332937
Rat
RGD:1563297
313596
Horse
transcription factor AP-2 epsilon
VGNC:50776
100069460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor AP-2 epsilon
Macaque
transcription factor AP-2 epsilon
Mouse
Rat
Horse
transcription factor AP-2 epsilon
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6VUC0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Activation of the TFAP2 (AP-2) family of transcription factors (R-HSA-8866907)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the TFAP2 (AP-2) family of transcription factors
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Activation of the TFAP2 (AP-2) family of transcription factors
Gene expression (Transcription)
Generic Transcription Pathway
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
RNA Polymerase II Transcription
Gene Ontology Terms (8)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (33)
1 – 10 of 33
KCTD1
Tbio
Novelty:  0.09964774
Score:  0.95
Data Source:  STRINGDB
KCTD15
Tbio
Novelty:  0.05277304
Score:  0.95
Data Source:  STRINGDB
CITED2
Tbio
Novelty:  0.01028104
Score:  0.919
Data Source:  STRINGDB
TFAP2D
Tdark
Family:  TF
Novelty:  0.18255944
Score:  0.919
Data Source:  STRINGDB
TFAP2B
Tbio
Family:  TF
Novelty:  0.01383202
Score:  0.916
Data Source:  STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
Score:  0.908
Data Source:  STRINGDB
TFAP2C
Tbio
Family:  TF
Novelty:  0.00893737
Score:  0.906
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.905
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.903
Data Source:  STRINGDB
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.52

PubMed score by year
PubTator Score  12.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer