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Tbio
RANBP10
Ran-binding protein 10

Protein Summary
Description
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317506
  • ENSP00000316589
  • ENSG00000141084
  • ENST00000448631
  • ENSP00000392808

Symbol
  • KIAA1464
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.92
histone modification site profile
0.88
kinase perturbation
0.84
gene perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
1
3
90.2
hematocrit
3
3
3
87.5
hemoglobin measurement
2
2
2
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
90.2
hematocrit
3
87.5
hemoglobin measurement
2
86.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAN binding protein 10
VGNC:5906
468004
Macaque
RAN binding protein 10
700911
Mouse
MGI:1921584
74334
Rat
RGD:1311587
361396
Dog
RAN binding protein 10 [Source:HGNC Symbol;Acc:HGNC:29285]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAN binding protein 10
Macaque
RAN binding protein 10
Mouse
Rat
Dog
RAN binding protein 10 [Source:HGNC Symbol;Acc:HGNC:29285]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6VN20-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
MET activates RAS signaling (R-HSA-8851805)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET activates RAS signaling
Reactome
Signal Transduction
Reactome
Signaling by MET
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
MET activates RAS signaling
Signal Transduction
Signaling by MET
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (76)
1 – 10 of 76
RMND5A
Tbio
Novelty: 0.01820349
p_int: 0.99990264
p_ni: 0.00009736
Score: 0.968
Data Source: BioPlex,STRINGDB
GCG
Tchem
Novelty: 0.00004879
p_int: 0.999689405
p_ni: 0.000310596
Data Source: BioPlex
PRG3
Tbio
Novelty: 0.09431986
p_int: 0.986741106
p_ni: 0.013258894
Data Source: BioPlex
PRICKLE3
Tbio
Novelty: 0.26347141
p_int: 0.98467734
p_ni: 0.01532266
Data Source: BioPlex
TIGD5
Tdark
Novelty: 1.93340494
p_int: 0.981836231
p_ni: 0.018163769
Data Source: BioPlex
BMP1
Tchem
Novelty: 0.00299518
p_int: 0.976941829
p_ni: 0.023058171
Data Source: BioPlex
INSL6
Tdark
Novelty: 0.06986187
p_int: 0.971691912
p_ni: 0.028308088
Score: 0.195
Data Source: BioPlex,STRINGDB
SPON1
Tbio
Novelty: 0.01071398
p_int: 0.964017503
p_ni: 0.035982497
Data Source: BioPlex
PRG2
Tbio
Novelty: 0.00548995
p_int: 0.961773082
p_ni: 0.038226918
Data Source: BioPlex
PIGT
Tbio
Family: Enzyme
Novelty: 0.02539879
p_int: 0.959416564
p_ni: 0.040583436
Data Source: BioPlex
Publication Statistics
PubMed Score  10.61

PubMed score by year
PubTator Score  5.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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