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Tbio
ATF7IP
Activating transcription factor 7-interacting protein 1

Protein Summary
Description
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261168
  • ENSP00000261168
  • ENSG00000171681
  • ENST00000536444
  • ENSP00000445955
  • ENST00000540793
  • ENSP00000444589
  • ENST00000543189
  • ENSP00000443179
  • ENST00000544627
  • ENSP00000440440

Symbol
  • MCAF
  • MCAF1
  • AM
  • MCAF
  • p621
  • MCAF1
  • ATF-IP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
kinase perturbation
0.91
transcription factor
0.77
biological process
0.74
hub protein
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.47   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.47   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
5.9
88.8
mathematical ability
3
3
3
80.9
intelligence
4
4
2
5.7
72.8
cognitive function measurement
1
1
1
61
household income
1
1
1
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.9
88.8
mathematical ability
3
80.9
intelligence
2
5.7
72.8
cognitive function measurement
1
61
household income
1
59.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 7 interacting protein
VGNC:4939
473374
Mouse
MGI:1858965
54343
Rat
RGD:1306030
312800
Dog
activating transcription factor 7 interacting protein
VGNC:38213
486674
Horse
activating transcription factor 7 interacting protein
VGNC:15614
100063778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activating transcription factor 7 interacting protein
Mouse
Rat
Dog
activating transcription factor 7 interacting protein
Horse
activating transcription factor 7 interacting protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6VMQ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (65)
1 – 10 of 65
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.999999965
p_ni:  3.4e-8
p_wrong:  1e-9
Score:  0.8
Data Source:  BioPlex,STRINGDB
ARL14EP
Tdark
Novelty:  0.58569411
p_int:  0.99999984
p_ni:  1.59e-7
p_wrong:  1e-9
Score:  0.959
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.999991771
p_ni:  0.000008228
p_wrong:  1e-9
Data Source:  BioPlex
MTRF1
Tbio
Family:  Enzyme
Novelty:  0.11037387
p_int:  0.999957454
p_ni:  0.000042544
p_wrong:  1e-9
Data Source:  BioPlex
PRR20E
Tdark
p_int:  0.999576636
p_ni:  0.000422964
p_wrong:  4e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
SUV39H1
Tchem
Family:  Epigenetic
Novelty:  0.00417439
p_int:  0.999566597
p_ni:  0.000433402
p_wrong:  1e-9
Score:  0.752
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999538093
p_ni:  0.000461906
p_wrong:  2e-9
Data Source:  BioPlex
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.99947597
p_ni:  0.000524026
p_wrong:  5e-9
Score:  0.27
Data Source:  BioPlex,STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.999049767
p_ni:  0.000947573
p_wrong:  0.00000266
Data Source:  BioPlex
Publication Statistics
PubMed Score  23.47

PubMed score by year
PubTator Score  19.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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