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Tbio
KSR2
Kinase suppressor of Ras 2

Protein Summary
Description
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339824
  • ENSP00000339952
  • ENSG00000171435
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
trait
0.93
protein domain
0.85
metabolite
0.82
cell type or tissue
0.68


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.6   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.6   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
3
1.1
96.5
body mass index
3
3
3
80.6
depressive symptom measurement
2
2
1
5.6
66.1
sleep duration
1
1
1
58.3
insomnia measurement
1
1
0
1
57.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
96.5
body mass index
3
80.6
depressive symptom measurement
1
5.6
66.1
sleep duration
1
58.3
insomnia measurement
0
1
57.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinase suppressor of ras 2
VGNC:52057
742520
Macaque
kinase suppressor of ras 2
694642
Mouse
MGI:3610315
333050
Rat
RGD:1562674
288691
Dog
kinase suppressor of ras 2
VGNC:42548
486291
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinase suppressor of ras 2
Macaque
kinase suppressor of ras 2
Mouse
Rat
Dog
kinase suppressor of ras 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6VAB6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (100)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (84)
1 – 10 of 84
MAP2K1
Tclin
Family: Kinase
Novelty: 0.0005278
Score: 0.998
Data Source: STRINGDB
MAP2K2
Tclin
Family: Kinase
Novelty: 0.00706525
Score: 0.989
Data Source: STRINGDB
CNKSR2
Tbio
Family: Enzyme
Novelty: 0.05451075
Score: 0.981
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.971
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.965
Data Source: STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
Score: 0.965
Data Source: STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00117121
Score: 0.961
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.957
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.954
Data Source: STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.60

PubMed score by year
PubTator Score  17.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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