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Tchem
DPP8
Dipeptidyl peptidase 8

Protein Summary
Description
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300141
  • ENSP00000300141
  • ENSG00000074603
  • ENST00000321147
  • ENSP00000318111
  • ENST00000341861
  • ENSP00000339208
  • ENST00000358939
  • ENSP00000351817
  • ENST00000559233
  • ENSP00000453954

Symbol
  • DPRP1
  • DP8
  • DPRP1
  • DPRP-1
  • MST097
  • MSTP097
  • MSTP135
  • MSTP141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
transcription factor binding site profile
0.87
transcription factor
0.66
histone modification site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.46   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.46   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 274
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (274)
1 – 10 of 274
talabostat
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CHEMBL210805
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Boronic acid derivative
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CHEMBL237336,CHEMBL189881
Rendered image for CHEMBL237336,CHEMBL189881
CHEMBL195189
Rendered image for CHEMBL195189
CHEMBL209940
Rendered image for CHEMBL209940
CHEMBL380090
Rendered image for CHEMBL380090
CHEMBL436744
Rendered image for CHEMBL436744
CHEMBL481669
Rendered image for CHEMBL481669
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
89.4
heel bone mineral density
2
2
3
88.5
mean reticulocyte volume
1
1
1
79.6
neutrophil count
1
1
1
69.8
monocyte percentage of leukocytes
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
89.4
heel bone mineral density
3
88.5
mean reticulocyte volume
1
79.6
neutrophil count
1
69.8
monocyte percentage of leukocytes
1
64.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 8
VGNC:7414
453518
Macaque
dipeptidyl peptidase 8
709428
Mouse
MGI:1921638
74388
Rat
RGD:1310901
315758
Dog
dipeptidyl peptidase 8
VGNC:40077
487605
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase 8
Macaque
dipeptidyl peptidase 8
Mouse
Rat
Dog
dipeptidyl peptidase 8
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6V1X1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.999999633
p_ni:  3.67e-7
Data Source:  BioPlex
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999997783
p_ni:  0.000002217
Data Source:  BioPlex
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999963474
p_ni:  0.000036526
Data Source:  BioPlex
IRAK3
Tchem
Family:  Kinase
Novelty:  0.01001206
p_int:  0.999927193
p_ni:  0.000072807
Data Source:  BioPlex
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
p_int:  0.999880169
p_ni:  0.00011983
p_wrong:  2e-9
Data Source:  BioPlex
IDO2
Tchem
Family:  Enzyme
Novelty:  0.01141558
p_int:  0.999759724
p_ni:  0.000240275
Score:  0.19
Data Source:  BioPlex,STRINGDB
CCL22
Tbio
Novelty:  0.00245992
p_int:  0.999711658
p_ni:  0.000288342
Score:  0.197
Data Source:  BioPlex,STRINGDB
IL17A
Tclin
Novelty:  0.00011583
p_int:  0.998987533
p_ni:  0.001012445
p_wrong:  2.3e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
ARHGEF16
Tbio
Novelty:  0.01856936
p_int:  0.996181821
p_ni:  0.003817804
p_wrong:  3.75e-7
Score:  0.201
Data Source:  BioPlex,STRINGDB
ATF2
Tbio
Family:  TF
Novelty:  0.00457832
p_int:  0.995456583
p_ni:  0.00454289
p_wrong:  5.27e-7
Score:  0.201
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  134.46

PubMed score by year
PubTator Score  79.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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