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Tbio
CYP26C1
Cytochrome P450 26C1

Protein Summary
Description
Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285949
  • ENSP00000285949
  • ENSG00000187553

Symbol
  • FFDD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
pathway
0.7
biological process
0.6
tissue sample
0.55
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.55   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.55   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
12
6
16
2.3
98
low density lipoprotein cholesterol measurement
5
4
6
95.8
apolipoprotein B measurement
2
4
4
93.2
high density lipoprotein cholesterol measurement
7
4
8
90.9
serum gamma-glutamyl transferase measurement
2
3
3
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
16
2.3
98
low density lipoprotein cholesterol measurement
6
95.8
apolipoprotein B measurement
4
93.2
high density lipoprotein cholesterol measurement
8
90.9
serum gamma-glutamyl transferase measurement
3
90.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 26C1
100610581
Mouse
MGI:2679699
546726
Rat
RGD:1308843
308190
Cow
cytochrome P450, family 26, subfamily C, polypeptide 1
539048
Pig
cytochrome P450 26C1
100739552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 26C1
Mouse
Rat
Cow
cytochrome P450, family 26, subfamily C, polypeptide 1
Pig
cytochrome P450 26C1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6V0L0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Disease
Diseases of metabolism
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (70)
1 – 10 of 70
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.964
Data Source:  STRINGDB
ALDH1A1
Tchem
Family:  Enzyme
Novelty:  0.0012292
Score:  0.953
Data Source:  STRINGDB
CRABP1
Tbio
Novelty:  0.00284292
Score:  0.941
Data Source:  Reactome,STRINGDB
CYP2S1
Tbio
Novelty:  0.02967417
Score:  0.927
Data Source:  STRINGDB
CYP4A11
Tbio
Novelty:  0.01121493
Score:  0.927
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.926
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.925
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.923
Data Source:  STRINGDB
CYP3A7
Tclin
Family:  Enzyme
Novelty:  0.00736888
Score:  0.923
Data Source:  STRINGDB
CYP3A5
Tclin
Family:  Enzyme
Novelty:  0.00105607
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.55

PubMed score by year
PubTator Score  11.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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