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Tbio
FAT4
Protocadherin Fat 4

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335110
  • ENSP00000335169
  • ENSG00000196159
  • ENST00000394329
  • ENSP00000377862

Symbol
  • CDHF14
  • FATJ
  • FATJ
  • FAT-J
  • CDHF14
  • CDHR11
  • HKLLS2
  • VMLDS2
  • NBLA00548
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
cell type or tissue
0.79
histone modification site profile
0.77
gene perturbation
0.66
phenotype
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.89   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.89   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
1
1
1
28.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
1
28.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FAT atypical cadherin 4
VGNC:598
471300
Macaque
FAT atypical cadherin 4
711867
Mouse
MGI:3045256
329628
Rat
RGD:1564291
310341
Dog
FAT atypical cadherin 4
VGNC:40745
483834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FAT atypical cadherin 4
Macaque
FAT atypical cadherin 4
Mouse
Rat
Dog
FAT atypical cadherin 4
Protein Structure (0 Structures, 19 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (83)
1 – 10 of 83
LIX1L
Tdark
Novelty: 0.5277858
p_int: 0.999985776
p_ni: 0.000014223
Score: 0.386
Data Source: BioPlex,STRINGDB
XAGE1A
Tbio
Novelty: 0.04421526
p_int: 0.999967228
p_ni: 0.000032772
Data Source: BioPlex
SIRT6
Tchem
Family: Epigenetic
Novelty: 0.00155366
p_int: 0.999950685
p_ni: 0.000049315
Data Source: BioPlex
C2orf48
Tdark
Novelty: 1
p_int: 0.999788876
p_ni: 0.000211124
Score: 0.2
Data Source: BioPlex,STRINGDB
CLU
Tbio
Novelty: 0.00054776
p_int: 0.999655832
p_ni: 0.000344168
Data Source: BioPlex
DKKL1
Tbio
Novelty: 0.00544618
p_int: 0.999492176
p_ni: 0.000507824
Data Source: BioPlex
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.999463804
p_ni: 0.000536196
Data Source: BioPlex
DCDC2B
Tdark
Novelty: 1.63648312
p_int: 0.998704411
p_ni: 0.001295589
Score: 0.217
Data Source: BioPlex,STRINGDB
PSG8
Tdark
Novelty: 0.1446257
p_int: 0.99868645
p_ni: 0.00131355
Data Source: BioPlex
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.998626426
p_ni: 0.001373574
Score: 0.174
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  64.89

PubMed score by year
PubTator Score  32.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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