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Tbio
ADAMTSL4
ADAMTS-like protein 4

Protein Summary
Description
Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271643
  • ENSP00000271643
  • ENSG00000143382
  • ENST00000369038
  • ENSP00000358034
  • ENST00000369039
  • ENSP00000358035
  • ENST00000369041
  • ENSP00000358037

Symbol
  • TSRC1
  • TSRC1
  • ECTOL2
  • ADAMTSL-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.77
gene perturbation
0.74
histone modification site profile
0.65
transcription factor binding site profile
0.6
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.32   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.32   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0