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Tbio
RSPO2
R-spondin-2

Protein Summary
Description
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21909076, PubMed:21727895, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720). This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat conta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276659
  • ENSP00000276659
  • ENSG00000147655
  • ENST00000517781
  • ENSP00000427937
  • ENST00000517939
  • ENSP00000428940

Symbol
  • HHRRD
  • TETAMS2
  • CRISTIN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.78
cell type or tissue
0.76
virus perturbation
0.68
disease
0.58
cell line
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.91   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.91   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
3
3
96.4
Alopecia
1
6
6
93.6
heel bone mineral density
2
4
4
79.7
1
1
1
67.1
hair color
1
2
0
1.2
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
96.4
Alopecia
6
93.6
heel bone mineral density
4
79.7
1
67.1
hair color
0
1.2
63.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
R-spondin 2
VGNC:13313
464335
Macaque
R-spondin 2
697376
Mouse
MGI:1922667
239405
Rat
RGD:1562331
500863
Dog
R-spondin 2
VGNC:45783
482004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
R-spondin 2
Macaque
R-spondin 2
Mouse
Rat
Dog
R-spondin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UXX9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Regulation of FZD by ubiquitination (R-HSA-4641263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Regulation of FZD by ubiquitination
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Regulation of FZD by ubiquitination
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (63)
1 – 10 of 63
ZNRF3
Tbio
Family:  Enzyme
Novelty:  0.03351825
Score:  0.996
Data Source:  Reactome,STRINGDB
LGR4
Tbio
Family:  GPCR
Novelty:  0.01180123
Score:  0.989
Data Source:  Reactome,STRINGDB
LGR5
Tbio
Family:  GPCR
Novelty:  0.00105035
Score:  0.981
Data Source:  Reactome,STRINGDB
RNF43
Tbio
Family:  Enzyme
Novelty:  0.01258908
Score:  0.973
Data Source:  Reactome,STRINGDB
LGR6
Tbio
Family:  GPCR
Novelty:  0.02186397
Score:  0.967
Data Source:  Reactome,STRINGDB
RSPO3
Tbio
Novelty:  0.02321039
Score:  0.912
Data Source:  STRINGDB
RSPO1
Tbio
Novelty:  0.00365075
Score:  0.91
Data Source:  STRINGDB
RSPO4
Tbio
Novelty:  0.05670413
Score:  0.907
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.902
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  73.91

PubMed score by year
PubTator Score  24.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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