Tbio GFRAL GDNF family receptor alpha-like

Protein Summary

Description

Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

Uniprot Accession IDs

• Q6UXV0
• Q5VTF6

Gene Name

• GFRAL

Ensembl ID

• ENST00000340465
• ENSP00000343636
• ENSG00000187871

Symbol

• C6orf144
• GRAL
• UNQ9356
• C6orf144
• bA360D14.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.44
microRNA	0.44
phenotype	0.44
tissue	0.43
tissue sample	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.86   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.86   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0