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Tbio
GFRAL
GDNF family receptor alpha-like

Protein Summary
Description
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340465
  • ENSP00000343636
  • ENSG00000187871

Symbol
  • C6orf144
  • GRAL
  • UNQ9356
  • C6orf144
  • bA360D14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.44
microRNA
0.44
phenotype
0.44
tissue
0.43
tissue sample
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.21   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.21   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
5
90.7
chronotype measurement
2
2
1
1.1
86
body mass index
1
1
1
24.8
blood urea nitrogen measurement
1
1
1
3.2
glomerular filtration rate
1
1
0
6.3
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
90.7
chronotype measurement
1
1.1
86
body mass index
1
24.8
blood urea nitrogen measurement
1
3.2
glomerular filtration rate
0
6.3
1.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GDNF family receptor alpha like
VGNC:2838
743306
Mouse
MGI:3607786
404194
Rat
RGD:1565220
501023
Dog
GDNF family receptor alpha like
VGNC:41192
481851
Horse
GDNF family receptor alpha like
VGNC:18319
100069686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GDNF family receptor alpha like
Mouse
Rat
Dog
GDNF family receptor alpha like
Horse
GDNF family receptor alpha like
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6UXV0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (12)
1 – 10 of 12
GDF15
Tbio
Novelty: 0.00098503
Score: 0.929
Data Source: STRINGDB
GAS1
Tbio
Novelty: 0.00423304
Score: 0.69
Data Source: STRINGDB
PSPN
Tbio
Novelty: 0.02169895
Score: 0.681
Data Source: STRINGDB
NRTN
Tbio
Novelty: 0.00547984
Score: 0.676
Data Source: STRINGDB
SARM1
Tbio
Novelty: 0.00510488
Score: 0.585
Data Source: STRINGDB
GDNF
Tbio
Novelty: 0.00036702
Score: 0.581
Data Source: STRINGDB
OR51Q1
Tdark
Family: oGPCR
Novelty: 5.05719446
Score: 0.53
Data Source: STRINGDB
C18orf21
Tdark
Novelty: 0.65363998
Score: 0.517
Data Source: STRINGDB
RPRD1A
Tbio
Novelty: 0.13521196
Score: 0.459
Data Source: STRINGDB
NABP2
Tbio
Novelty: 0.09046897
Score: 0.43
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.21

PubMed score by year
PubTator Score  17.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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