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Tbio
WDR82
WD repeat-containing protein 82

Protein Summary
Description
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296490
  • ENSP00000296490
  • ENSG00000164091

Symbol
  • TMEM113
  • WDR82A
  • SWD2
  • MST107
  • WDR82A
  • MSTP107
  • PRO2730
  • TMEM113
  • PRO34047
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.97
microRNA
0.77
protein domain
0.73
cellular component
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.14   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.14   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
1
1
67.7
BMI-adjusted waist-hip ratio
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
67.7
BMI-adjusted waist-hip ratio
1
6.9
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (184)
1 – 10 of 184
RBBP5
Tbio
Novelty: 0.02221059
Score: 0.998
Data Source: STRINGDB
SETD1B
Tbio
Family: Epigenetic
Novelty: 0.03331663
Score: 0.997
Data Source: STRINGDB
ASH2L
Tbio
Family: Enzyme
Novelty: 0.01586766
Score: 0.997
Data Source: STRINGDB
DPY30
Tbio
Novelty: 0.03098629
Score: 0.996
Data Source: STRINGDB
SETD1A
Tbio
Family: Epigenetic
Novelty: 0.00248544
Score: 0.996
Data Source: STRINGDB
SSU72
Tbio
Family: Enzyme
Novelty: 0.02342759
Score: 0.992
Data Source: STRINGDB
CXXC1
Tbio
Family: Epigenetic
Novelty: 0.01019251
Score: 0.991
Data Source: STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
Score: 0.985
Data Source: STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
Score: 0.985
Data Source: STRINGDB
WDR5
Tchem
Novelty: 0.0059945
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.14

PubMed score by year
PubTator Score  6.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer