Tbio TREML4 Trem-like transcript 4 protein

Protein Summary

Description

Positively regulates Toll-like receptor TLR7 signaling in macrophages.

Uniprot Accession IDs

• Q6UXN2
• B7ZL92
• TLT-4

Gene Name

• TREML4

Ensembl ID

• ENST00000341495
• ENSP00000342570
• ENSG00000188056
• ENST00000448827
• ENSP00000418078

Symbol

• TLT4
• TLT4
• TLT-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.67
microRNA	0.65
cell line	0.64
tissue sample	0.59
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.94   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.94   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (14)

Explore Interacting Targets

1 – 10 of 14

• See Interactions on String-DB

TREML1

Tbio

Novelty:  0.03513416

Score:  0.668

Data Source:  STRINGDB

TREM1

Tbio

Novelty:  0.00249253

Score:  0.646

Data Source:  STRINGDB

RRAS2

Tbio

Family:  Enzyme

Novelty:  0.01870067

Score:  0.645

Data Source:  STRINGDB

CLEC9A

Tbio

Novelty:  0.01680318

Score:  0.641

Data Source:  STRINGDB

TREM2

Tbio

Novelty:  0.00228007

Score:  0.586

Data Source:  STRINGDB

TYROBP

Tbio

Family:  Enzyme

Novelty:  0.00410031

Score:  0.554

Data Source:  STRINGDB

CD300LB

Tbio

Novelty:  0.10587821

Score:  0.515

Data Source:  STRINGDB

CLEC5A

Tbio

Novelty:  0.01710591

Score:  0.508

Data Source:  STRINGDB

RHOG

Tbio

Family:  Enzyme

Novelty:  0.00412327

Score:  0.492

Data Source:  STRINGDB

C4orf17

Tdark

Novelty:  1.74934388

Score:  0.473

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Adaptive Immune System (R-HSA-1280218)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Immune System	2246 targets	R-HSA-168256
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	275 targets	R-HSA-198933

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Components (2)

Processes (3)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
plasma membrane	Traceable Author Statement (TAS)	Reactome
extracellular region	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations (null)

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	2	2	2		87.7
late-onset Alzheimers disease	EFO_1001870	1	2	0	2.1	87.7
Alzheimer's disease	EFO_0000249	2	2	0	4.2	66.6
leukocyte count	EFO_0004308	1	1	1		64.4
reticulocyte count	EFO_0007986	1	1	1		46.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte count	EFO_0005091	2		87.7
late-onset Alzheimers disease	EFO_1001870	0	2.1	87.7
Alzheimer's disease	EFO_0000249	0	4.2	66.6
leukocyte count	EFO_0004308	1		64.4
reticulocyte count	EFO_0007986	1		46.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Immunoglobulin domain
Innate immunity
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
Alzheimer's disease
C-reactive protein measurement
family history of Alzheimer’s disease
late-onset Alzheimers disease
leukocyte count
monocyte count
reticulocyte count

IDG Resources

No IDG generated resources found

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	triggering receptor expressed on myeloid cells like 4	VGNC:12726	107975132
Mouse	triggering receptor expressed on myeloid cells-like 4	MGI:1923239	224840
Rat	triggering receptor expressed on myeloid cells-like 4	RGD:1587021	680862

Species	Name	OMA	EggNOG	Inparanoid
Chimp	triggering receptor expressed on myeloid cells like 4
Mouse	triggering receptor expressed on myeloid cells-like 4
Rat	triggering receptor expressed on myeloid cells-like 4

Publication Statistics

PubMed Score 6.94

PubMed score by year

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PubTator Score 2.57

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title