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Tbio
TREML4
Trem-like transcript 4 protein

Protein Summary
Description
Positively regulates Toll-like receptor TLR7 signaling in macrophages.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341495
  • ENSP00000342570
  • ENSG00000188056
  • ENST00000448827
  • ENSP00000418078

Symbol
  • TLT4
  • TLT4
  • TLT-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
microRNA
0.65
cell line
0.64
tissue sample
0.59
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.94   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.94   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
TREML1
Tbio
Novelty:  0.03513416
Score:  0.668
Data Source:  STRINGDB
TREM1
Tbio
Novelty:  0.00249253
Score:  0.646
Data Source:  STRINGDB
RRAS2
Tbio
Family:  Enzyme
Novelty:  0.01870067
Score:  0.645
Data Source:  STRINGDB
CLEC9A
Tbio
Novelty:  0.01680318
Score:  0.641
Data Source:  STRINGDB
TREM2
Tbio
Novelty:  0.00228007
Score:  0.586
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.554
Data Source:  STRINGDB
CD300LB
Tbio
Novelty:  0.10587821
Score:  0.515
Data Source:  STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.508
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.492
Data Source:  STRINGDB
C4orf17
Tdark
Novelty:  1.74934388
Score:  0.473
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
87.7
late-onset Alzheimers disease
1
2
0
2.1
87.7
2
2
0
4.2
66.6
leukocyte count
1
1
1
64.4
reticulocyte count
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
87.7
late-onset Alzheimers disease
0
2.1
87.7
0
4.2
66.6
leukocyte count
1
64.4
reticulocyte count
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
triggering receptor expressed on myeloid cells like 4
VGNC:12726
107975132
Mouse
MGI:1923239
224840
Rat
RGD:1587021
680862
Species
Name
OMA
EggNOG
Inparanoid
Chimp
triggering receptor expressed on myeloid cells like 4
Mouse
Rat
Publication Statistics
PubMed Score 6.94
PubMed score by year
PubTator Score 2.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title