You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

Protein Classes
Protein Summary
Description
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320743
  • ENSP00000326759
  • ENSG00000139263
  • ENST00000379141
  • ENSP00000368436

Symbol
  • LIG3
  • LIG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.84
PubMedID
0.76
transcription factor binding site profile
0.76
tissue sample
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.44   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.44   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
1
1
0
1.2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
0
1.2
35
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and immunoglobulin like domains 3
VGNC:8463
452033
Macaque
leucine rich repeats and immunoglobulin like domains 3
716344
Mouse
MGI:2443955
320398
Dog
leucine rich repeats and immunoglobulin like domains 3
VGNC:42769
474423
Horse
leucine rich repeats and immunoglobulin like domains 3
VGNC:19755
100054709
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and immunoglobulin like domains 3
Macaque
leucine rich repeats and immunoglobulin like domains 3
Mouse
Dog
leucine rich repeats and immunoglobulin like domains 3
Horse
leucine rich repeats and immunoglobulin like domains 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UXM1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (48)
1 – 10 of 48
LRIG1
Tbio
Novelty:  0.01078663
p_int:  0.999983983
p_ni:  0.000016016
p_wrong:  1e-9
Score:  0.736
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.984114808
p_ni:  0.015885192
Data Source:  BioPlex
LRRN2
Tdark
Novelty:  0.22583761
p_int:  0.977789604
p_ni:  0.022210396
Score:  0.308
Data Source:  BioPlex,STRINGDB
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
p_int:  0.958227777
p_ni:  0.041772223
Data Source:  BioPlex
GAL3ST1
Tbio
Family:  Enzyme
Novelty:  0.02939055
p_int:  0.950202922
p_ni:  0.049797078
Score:  0.907
Data Source:  BioPlex,STRINGDB
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
p_int:  0.937989296
p_ni:  0.062010704
Score:  0.209
Data Source:  BioPlex,STRINGDB
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.839471668
p_ni:  0.160528238
p_wrong:  9.4e-8
Data Source:  BioPlex
MAN1A1
Tbio
Family:  Enzyme
Novelty:  0.00645679
p_int:  0.771462949
p_ni:  0.228537051
Data Source:  BioPlex
KDELR2
Tbio
Novelty:  0.12002642
Score:  0.764
Data Source:  STRINGDB
SLC34A2
Tchem
Family:  Transporter
Novelty:  0.00601743
Score:  0.757
Data Source:  STRINGDB
Publication Statistics
PubMed Score  25.44

PubMed score by year
PubTator Score  21.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: