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Tbio
IL20RB
Interleukin-20 receptor subunit beta

Protein Summary
Description
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329582
  • ENSP00000328133
  • ENSG00000174564

Symbol
  • DIRS1
  • DIRS1
  • FNDC6
  • IL-20R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
cell type or tissue
0.74
biological process
0.73
gene perturbation
0.65
tissue sample
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.73   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.73   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
9
4
5.9
82.2
myeloid white cell count
1
1
1
68.2
puberty onset measurement
1
1
1
57.9
cognitive function measurement
3
2
3
17.1
leukocyte count
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
5.9
82.2
myeloid white cell count
1
68.2
puberty onset measurement
1
57.9
cognitive function measurement
3
17.1
leukocyte count
1
8.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (88)
1 – 10 of 88
NMU
Tbio
Novelty: 0.00326109
p_int: 0.997241854
p_ni: 0.001040157
p_wrong: 0.001717989
Score: 0.188
Data Source: BioPlex,STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.996665266
p_ni: 0.003334734
Data Source: BioPlex
B4GALT5
Tbio
Family: Enzyme
Novelty: 0.04538678
p_int: 0.985834138
p_ni: 0.014165862
Score: 0.169
Data Source: BioPlex,STRINGDB
MYADM
Tbio
Novelty: 0.11475375
p_int: 0.956769674
p_ni: 0.043227761
p_wrong: 0.000002564
Score: 0.177
Data Source: BioPlex,STRINGDB
POM121
Tbio
Novelty: 0.01691523
p_int: 0.955661544
p_ni: 0.044338456
Score: 0.512
Data Source: BioPlex,STRINGDB
APP
Tchem
Novelty: 0.00008964
p_int: 0.952638218
p_ni: 0.047361782
Data Source: BioPlex
ZDHHC9
Tbio
Family: Enzyme
Novelty: 0.04949094
p_int: 0.897038615
p_ni: 0.090504981
p_wrong: 0.012456404
Score: 0.173
Data Source: BioPlex,STRINGDB
DHRS7
Tbio
Family: Enzyme
Novelty: 0.16713756
p_int: 0.792025158
p_ni: 0.207974842
Data Source: BioPlex
TMEM59
Tbio
Novelty: 0.0329414
p_int: 0.760362705
p_ni: 0.239637295
Score: 0.54
Data Source: BioPlex,STRINGDB
IL20
Tbio
Novelty: 0.78184288
Score: 0.993
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  62.73

PubMed score by year
PubTator Score  16.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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