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Tbio
IL20RB
Interleukin-20 receptor subunit beta

Protein Summary
Description
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329582
  • ENSP00000328133
  • ENSG00000174564

Symbol
  • DIRS1
  • DIRS1
  • FNDC6
  • IL-20R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
cell type or tissue
0.74
biological process
0.73
gene perturbation
0.65
tissue sample
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.46   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.46   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
NMU
Tbio
Novelty:  0.00326109
p_int:  0.997241854
p_ni:  0.001040157
p_wrong:  0.001717989
Score:  0.188
Data Source:  BioPlex,STRINGDB
P10314
Tbio
Novelty:  0.00270731
p_int:  0.996665266
p_ni:  0.003334734
Data Source:  BioPlex
B4GALT5
Tbio
Family:  Enzyme
Novelty:  0.04538678
p_int:  0.985834138
p_ni:  0.014165862
Score:  0.169
Data Source:  BioPlex,STRINGDB
MYADM
Tbio
Novelty:  0.11475375
p_int:  0.956769674
p_ni:  0.043227761
p_wrong:  0.000002564
Score:  0.177
Data Source:  BioPlex,STRINGDB
POM121
Tbio
Novelty:  0.01691523
p_int:  0.955661544
p_ni:  0.044338456
Score:  0.512
Data Source:  BioPlex,STRINGDB
APP
Tclin
Novelty:  0.00008964
p_int:  0.952638218
p_ni:  0.047361782
Data Source:  BioPlex
ZDHHC9
Tbio
Family:  Enzyme
Novelty:  0.04949094
p_int:  0.897038615
p_ni:  0.090504981
p_wrong:  0.012456404
Score:  0.173
Data Source:  BioPlex,STRINGDB
DHRS7
Tbio
Family:  Enzyme
Novelty:  0.16713756
p_int:  0.792025158
p_ni:  0.207974842
Data Source:  BioPlex
TMEM59
Tbio
Novelty:  0.0329414
p_int:  0.760362705
p_ni:  0.239637295
Score:  0.54
Data Source:  BioPlex,STRINGDB
IL20
Tbio
Novelty:  0.78184288
Score:  0.993
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
Pathways (9)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
1
2
83.8
blood urea nitrogen measurement
1
1
1
69.1
monocyte count
1
1
1
59.8
platelet count
1
1
1
56.8
myeloid white cell count
1
1
1
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
83.8
blood urea nitrogen measurement
1
69.1
monocyte count
1
59.8
platelet count
1
56.8
myeloid white cell count
1
56
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 20 receptor subunit beta
VGNC:1846
742595
Macaque
interleukin 20 receptor subunit beta
716769
Mouse
MGI:2143266
213208
Rat
RGD:1566151
501043
Dog
interleukin 20 receptor subunit beta
VGNC:41966
610961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 20 receptor subunit beta
Macaque
interleukin 20 receptor subunit beta
Mouse
Rat
Dog
interleukin 20 receptor subunit beta
Publication Statistics
PubMed Score 80.46
PubMed score by year
PubTator Score 16.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title