Tbio NPNT Nephronectin

Protein Summary

Description

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).

Uniprot Accession IDs

• Q6UXI9
• A6NFT9
• A8K1W4
• B4DIT4
• B4DYK3
• B4E2H7
• B4E3H2
• D6RCA1
• E9PCK8
• E9PCQ1
• E9PE64
• E9PF04

Gene Name

• NPNT

Ensembl ID

• ENST00000305572
• ENSP00000302557
• ENSG00000168743
• ENST00000379987
• ENSP00000369323
• ENST00000427316
• ENSP00000389252
• ENST00000453617
• ENSP00000402884
• ENST00000506666
• ENSP00000422474
• ENST00000514622
• ENSP00000422044

Symbol

• EGFL6L
• POEM
• POEM
• EGFL6L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
gene perturbation	0.95
biological process	0.91
transcription factor perturbation	0.88
cellular component	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.46   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.46   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0