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Tbio
KIAA1324
UPF0577 protein KIAA1324

Protein Summary
Description
May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369939
  • ENSP00000358955
  • ENSG00000116299
  • ENST00000529753
  • ENSP00000434595

Symbol
  • EIG121
  • EIG121
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.94
transcription factor perturbation
0.88
cell type or tissue
0.84
histone modification site profile
0.72
PubMedID
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.5   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.5   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
HACE1
Tbio
Family:  Enzyme
Novelty:  0.10173082
Score:  0.919
Data Source:  STRINGDB
CTNND2
Tbio
Novelty:  0.01178779
Score:  0.627
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.544
Data Source:  STRINGDB
CALCR
Tclin
Family:  GPCR
Novelty:  0.00112487
Score:  0.52
Data Source:  STRINGDB
CIB1
Tbio
Novelty:  0.00364869
Score:  0.513
Data Source:  STRINGDB
GOLIM4
Tbio
Novelty:  0.01923513
Score:  0.502
Data Source:  STRINGDB
SREK1
Tbio
Novelty:  0.19228162
Score:  0.456
Data Source:  STRINGDB
SPNS3
Tdark
Novelty:  0.40832952
Score:  0.445
Data Source:  STRINGDB
SRSF6
Tbio
Novelty:  0.00396762
Score:  0.437
Data Source:  STRINGDB
ACTL6A
Tbio
Novelty:  0.01892162
Score:  0.437
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
27
29
66
5.5
99.9
apolipoprotein B measurement
3
24
26
99.9
total cholesterol measurement
16
22
50
6.2
99.9
apolipoprotein A 1 measurement
3
5
5
98.3
13
6
4
1.1
98.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
66
5.5
99.9
apolipoprotein B measurement
26
99.9
total cholesterol measurement
50
6.2
99.9
apolipoprotein A 1 measurement
5
98.3
4
1.1
98.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
KIAA1324 ortholog
697670
Mouse
MGI:1923930
229722
Dog
KIAA1324
VGNC:42364
479917
Horse
KIAA1324
VGNC:19377
100058066
Cow
KIAA1324
VGNC:30567
784449
Species
Name
OMA
EggNOG
Inparanoid
Macaque
KIAA1324 ortholog
Mouse
Dog
KIAA1324
Horse
KIAA1324
Cow
KIAA1324
Publication Statistics
PubMed Score 14.50
PubMed score by year
PubTator Score 8.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title