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Tbio
TMEM108
Transmembrane protein 108

Protein Summary
Description
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321871
  • ENSP00000324651
  • ENSG00000144868
  • ENST00000393130
  • ENSP00000376838

Symbol
  • KIAA1690
  • RTLN
  • RTLN
  • CT124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
trait
0.86
histone modification site profile
0.66
cell type or tissue
0.64
PubMedID
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
49.5
daytime rest measurement
1
1
1
35
chronotype measurement
1
1
1
29
disease progression measurement
1
1
0
2.9
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
49.5
daytime rest measurement
1
35
chronotype measurement
1
29
disease progression measurement
0
2.9
21.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 108
VGNC:2608
104005747
Macaque
transmembrane protein 108
717579
Mouse
MGI:1932411
81907
Rat
RGD:1311530
300967
Dog
transmembrane protein 108
VGNC:47449
485667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 108
Macaque
transmembrane protein 108
Mouse
Rat
Dog
transmembrane protein 108
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UXF1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (19)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (43)
1 – 10 of 43
RRN3
Tbio
Family:  Enzyme
Novelty:  0.01643149
p_int:  0.999986885
p_ni:  0.000013076
p_wrong:  3.9e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.999913591
p_ni:  0.000086408
Data Source:  BioPlex
POU2F2
Tbio
Family:  TF
Novelty:  0.02531524
p_int:  0.999353214
p_ni:  0.000003707
p_wrong:  0.000643079
Score:  0.277
Data Source:  BioPlex,STRINGDB
SLC25A24
Tbio
Family:  Transporter
Novelty:  0.06151955
p_int:  0.998973255
p_ni:  0.001026744
Data Source:  BioPlex
MTFP1
Tbio
Novelty:  0.01899273
p_int:  0.982344316
p_ni:  0.017396145
p_wrong:  0.000259539
Score:  0.169
Data Source:  BioPlex,STRINGDB
SLC25A23
Tbio
Family:  Transporter
Novelty:  0.10446757
p_int:  0.980701168
p_ni:  0.019136134
p_wrong:  0.000162698
Data Source:  BioPlex
SFXN5
Tdark
Novelty:  0.30379915
p_int:  0.975058685
p_ni:  0.023710935
p_wrong:  0.001230381
Data Source:  BioPlex
PDXDC1
Tbio
Family:  Enzyme
Novelty:  0.16529476
p_int:  0.965404245
p_ni:  0.034595755
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.965281576
p_ni:  0.034718424
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.934623309
p_ni:  0.065376691
Data Source:  BioPlex
Publication Statistics
PubMed Score  11.08

PubMed score by year
PubTator Score  0.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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