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Tdark
SLC49A3
Solute carrier family 49 member A3

Related Tools
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.41   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.41   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
90.3
myeloid white cell count
2
2
2
89.7
monocyte percentage of leukocytes
2
2
2
89.5
leukocyte count
2
2
2
86.2
3
2
2
1.1
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
90.3
myeloid white cell count
2
89.7
monocyte percentage of leukocytes
2
89.5
leukocyte count
2
86.2
2
1.1
83.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 49 member 3
VGNC:637
461044
Mouse
MGI:2442629
243197
Rat
RGD:1304688
305625
Dog
solute carrier family 49 member 3
VGNC:43207
488870
Horse
solute carrier family 49 member 3
VGNC:20156
100051663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 49 member 3
Mouse
Rat
Dog
solute carrier family 49 member 3
Horse
solute carrier family 49 member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UXD7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (29)
1 – 10 of 29
UVSSA
Tbio
Novelty:  0.06728258
Score:  0.663
Data Source:  STRINGDB
IDUA
Tbio
Family:  Enzyme
Novelty:  0.00288117
Score:  0.651
Data Source:  STRINGDB
DGKQ
Tbio
Family:  Kinase
Novelty:  0.01973121
Score:  0.642
Data Source:  STRINGDB
PIGG
Tbio
Family:  Enzyme
Novelty:  0.01573185
Score:  0.64
Data Source:  STRINGDB
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
Score:  0.587
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.538
Data Source:  STRINGDB
MFSD5
Tdark
Novelty:  0.58146966
Score:  0.529
Data Source:  STRINGDB
TBRG4
Tbio
Novelty:  0.03556613
Score:  0.509
Data Source:  STRINGDB
MFSD4B
Tdark
Novelty:  0.03380333
Score:  0.494
Data Source:  STRINGDB
RNF212B
Tdark
Novelty:  1.20319873
Score:  0.493
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.41

PubMed score by year
PubTator Score  0.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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