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Tbio
PLXDC2
Plexin domain-containing protein 2

Protein Summary
Description
May play a role in tumor angiogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377242
  • ENSP00000366450
  • ENSG00000120594
  • ENST00000377252
  • ENSP00000366460

Symbol
  • TEM7R
  • TEM7R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor perturbation
0.84
histone modification site profile
0.75
PubMedID
0.75
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.9   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.9   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
9
92.8
prothrombin time measurement
1
1
1
71.3
coagulation factor V measurement
1
1
1
62.6
self reported educational attainment
1
2
2
40.5
mathematical ability
1
2
2
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
9
92.8
prothrombin time measurement
1
71.3
coagulation factor V measurement
1
62.6
self reported educational attainment
2
40.5
mathematical ability
2
37.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plexin domain containing 2
VGNC:12428
450338
Macaque
plexin domain containing 2
702523
Mouse
MGI:1914698
67448
Rat
RGD:1305962
361282
Dog
plexin domain containing 2
VGNC:44717
608632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plexin domain containing 2
Macaque
plexin domain containing 2
Mouse
Rat
Dog
plexin domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UX71-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (67)
1 – 10 of 67
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.999959484
p_ni:  0.000040373
p_wrong:  1.43e-7
Data Source:  BioPlex
CCDC115
Tbio
Novelty:  0.23966137
p_int:  0.999874434
p_ni:  0.00012545
p_wrong:  1.16e-7
Score:  0.243
Data Source:  BioPlex,STRINGDB
AKR1C4
Tchem
Family:  Enzyme
Novelty:  0.00925635
p_int:  0.999655887
p_ni:  0.000344113
Score:  0.241
Data Source:  BioPlex,STRINGDB
ZFYVE27
Tbio
Novelty:  0.0563358
p_int:  0.996551019
p_ni:  0.003448981
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.993562905
p_ni:  0.006437095
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.991238909
p_ni:  0.008761086
p_wrong:  4e-9
Data Source:  BioPlex
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.991036731
p_ni:  0.008963268
p_wrong:  1e-9
Data Source:  BioPlex
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.990165006
p_ni:  0.009834969
p_wrong:  2.5e-8
Data Source:  BioPlex
LRRC42
Tdark
Novelty:  1.83168269
p_int:  0.990087789
p_ni:  0.009912211
Score:  0.211
Data Source:  BioPlex,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.982226781
p_ni:  0.017773218
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  16.90

PubMed score by year
PubTator Score  7.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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