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Tbio
DRAM2
DNA damage-regulated autophagy modulator protein 2

Protein Summary
Description
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286692
  • ENSP00000286692
  • ENSG00000156171
  • ENST00000539140
  • ENSP00000437718

Symbol
  • TMEM77
  • CORD21
  • PRO180
  • TMEM77
  • WWFQ154
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor perturbation
0.8
tissue sample
0.74
transcription factor binding site profile
0.67
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (13)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (15)
1 – 10 of 15
DENND2D
Tbio
Novelty: 0.15344114
Score: 0.769
Data Source: STRINGDB
TSPAN2
Tbio
Novelty: 0.06336311
Score: 0.679
Data Source: STRINGDB
C11orf87
Tdark
Score: 0.653
Data Source: STRINGDB
GPR37L1
Tbio
Family: GPCR
Novelty: 0.11748252
Score: 0.633
Data Source: STRINGDB
MAB21L2
Tbio
Novelty: 0.05944378
Score: 0.626
Data Source: STRINGDB
TMEM87A
Tdark
Novelty: 2
Score: 0.547
Data Source: STRINGDB
BECN1
Tbio
Novelty: 0.00046615
Score: 0.542
Data Source: STRINGDB
POC1B
Tbio
Novelty: 0.11982426
Score: 0.511
Data Source: STRINGDB
PDSS2
Tbio
Family: Enzyme
Novelty: 0.01416723
Score: 0.5
Data Source: STRINGDB
TMEM17
Tbio
Novelty: 2.54545455
Score: 0.465
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.52

PubMed score by year
PubTator Score  8.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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