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Tbio
DRAM2
DNA damage-regulated autophagy modulator protein 2

Protein Summary
Description
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286692
  • ENSP00000286692
  • ENSG00000156171
  • ENST00000539140
  • ENSP00000437718

Symbol
  • TMEM77
  • CORD21
  • PRO180
  • TMEM77
  • WWFQ154
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor perturbation
0.8
tissue sample
0.74
transcription factor binding site profile
0.67
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.5   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.5   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
32.6
mean reticulocyte volume
1
1
1
31.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
32.6
mean reticulocyte volume
1
31.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA damage regulated autophagy modulator 2
VGNC:6784
457117
Macaque
DNA damage regulated autophagy modulator 2
702812
Mouse
MGI:1914421
67171
Rat
RGD:1564099
362011
Dog
DNA damage regulated autophagy modulator 2
VGNC:40089
479905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA damage regulated autophagy modulator 2
Macaque
DNA damage regulated autophagy modulator 2
Mouse
Rat
Dog
DNA damage regulated autophagy modulator 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UX65-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (15)
1 – 10 of 15
DENND2D
Tbio
Novelty: 0.16496649
Score: 0.769
Data Source: STRINGDB
TSPAN2
Tbio
Novelty: 0.03842973
Score: 0.679
Data Source: STRINGDB
C11orf87
Tdark
Novelty: 1.33249342
Score: 0.653
Data Source: STRINGDB
GPR37L1
Tbio
Family: GPCR
Novelty: 0.08467087
Score: 0.633
Data Source: STRINGDB
MAB21L2
Tbio
Novelty: 0.05770595
Score: 0.626
Data Source: STRINGDB
TMEM87A
Tdark
Novelty: 0.33614983
Score: 0.547
Data Source: STRINGDB
BECN1
Tbio
Novelty: 0.0003792
Score: 0.542
Data Source: STRINGDB
POC1B
Tbio
Novelty: 0.09023863
Score: 0.511
Data Source: STRINGDB
PDSS2
Tbio
Family: Enzyme
Novelty: 0.02716477
Score: 0.5
Data Source: STRINGDB
TMEM17
Tbio
Novelty: 0.42919021
Score: 0.465
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.50

PubMed score by year
PubTator Score  8.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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