Protein Summary
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
- ENST00000339336
- ENSP00000341013
- ENSG00000187689
- ENST00000504451
- ENSP00000422452
- AI3B
- UNQ689
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
tissue | 0.57 | ||
cell type or tissue | 0.54 | ||
gene perturbation | 0.47 | ||
cell line | 0.45 | ||
cellular component | 0.37 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.75 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.75 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (142)
LRRC40
Novelty: 2.43377466
p_int: 0.911833113
p_ni: 0.087648176
p_wrong: 0.000518711
Score: 0.169
Data Source: BioPlex,STRINGDB
SEC24D
Novelty: 0.04795527
p_int: 0.883337062
p_ni: 0.116113738
p_wrong: 0.0005492
Score: 0.221
Data Source: BioPlex,STRINGDB
PTPN1
Family: Enzyme
Novelty: 0.00065779
p_int: 0.877835361
p_ni: 0.122109527
p_wrong: 0.000055112
Score: 0.173
Data Source: BioPlex,STRINGDB
RABL6
Family: Enzyme
Novelty: 0.11501478
p_int: 0.863122708
p_ni: 0.10557725
p_wrong: 0.031300042
Score: 0.19
Data Source: BioPlex,STRINGDB
NARS
Family: Enzyme
Novelty: 0.01124207
p_int: 0.816597676
p_ni: 0.131236017
p_wrong: 0.052166307
Data Source: BioPlex
CYB5R3
Family: Enzyme
Novelty: 0.00774258
p_int: 0.798670293
p_ni: 0.201329705
p_wrong: 2e-9
Data Source: BioPlex
PPID
Family: Enzyme
Novelty: 0.01068886
p_int: 0.796564206
p_ni: 0.057192544
p_wrong: 0.14624325
Score: 0.188
Data Source: BioPlex,STRINGDB
CDK5RAP3
Novelty: 0.03628071
p_int: 0.758779359
p_ni: 0.241028675
p_wrong: 0.000191966
Score: 0.173
Data Source: BioPlex,STRINGDB
GINS4
Novelty: 0.0316194
p_int: 0.757598432
p_ni: 0.242298984
p_wrong: 0.000102584
Score: 0.19
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | HGNC | |||
Inferred from Sequence or structural Similarity (ISS) | HGNC | |||
Inferred from Sequence or structural Similarity (ISS) | HGNC | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 32.4 | 2.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 32.4 | 2.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | amelotin | VGNC:697 | 742016 | |||||
Macaque | amelotin | 707054 | ||||||
Mouse | MGI:1918671 | 71421 | ||||||
Rat | RGD:1592356 | 689404 | ||||||
Dog | amelotin | VGNC:37841 | 611794 | |||||
Publication Statistics
PubMed Score 44.75
PubMed score by year
PubTator Score 8.17
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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