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Tbio
AMTN
Amelotin

Protein Summary
Description
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339336
  • ENSP00000341013
  • ENSG00000187689
  • ENST00000504451
  • ENSP00000422452

Symbol
  • AI3B
  • UNQ689
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.57
cell type or tissue
0.54
gene perturbation
0.47
cell line
0.45
cellular component
0.37


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.75   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.75   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diabetic nephropathy
1
1
0
32.4
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diabetic nephropathy
0
32.4
2.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amelotin
VGNC:697
742016
Macaque
amelotin
707054
Mouse
MGI:1918671
71421
Rat
RGD:1592356
689404
Dog
amelotin
VGNC:37841
611794
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amelotin
Macaque
amelotin
Mouse
Rat
Dog
amelotin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UX39-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Sequence or structural Similarity (ISS)
HGNC
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (142)
1 – 10 of 142
LRRC40
Tdark
Novelty:  2.43377466
p_int:  0.911833113
p_ni:  0.087648176
p_wrong:  0.000518711
Score:  0.169
Data Source:  BioPlex,STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
p_int:  0.883337062
p_ni:  0.116113738
p_wrong:  0.0005492
Score:  0.221
Data Source:  BioPlex,STRINGDB
PTPN1
Tchem
Family:  Enzyme
Novelty:  0.00065779
p_int:  0.877835361
p_ni:  0.122109527
p_wrong:  0.000055112
Score:  0.173
Data Source:  BioPlex,STRINGDB
RABL6
Tbio
Family:  Enzyme
Novelty:  0.11501478
p_int:  0.863122708
p_ni:  0.10557725
p_wrong:  0.031300042
Score:  0.19
Data Source:  BioPlex,STRINGDB
NARS
Tbio
Family:  Enzyme
Novelty:  0.01124207
p_int:  0.816597676
p_ni:  0.131236017
p_wrong:  0.052166307
Data Source:  BioPlex
CYB5R3
Tbio
Family:  Enzyme
Novelty:  0.00774258
p_int:  0.798670293
p_ni:  0.201329705
p_wrong:  2e-9
Data Source:  BioPlex
PPID
Tchem
Family:  Enzyme
Novelty:  0.01068886
p_int:  0.796564206
p_ni:  0.057192544
p_wrong:  0.14624325
Score:  0.188
Data Source:  BioPlex,STRINGDB
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.758779359
p_ni:  0.241028675
p_wrong:  0.000191966
Score:  0.173
Data Source:  BioPlex,STRINGDB
GINS4
Tbio
Novelty:  0.0316194
p_int:  0.757598432
p_ni:  0.242298984
p_wrong:  0.000102584
Score:  0.19
Data Source:  BioPlex,STRINGDB
ENAM
Tbio
Novelty:  0.00593293
Score:  0.989
Data Source:  STRINGDB
Publication Statistics
PubMed Score  44.75

PubMed score by year
PubTator Score  8.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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