Tbio AMTN Amelotin

Protein Summary

Description

Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6UX39
• Q0P503
• Q0P506

Gene Name

• AMTN

Ensembl ID

• ENST00000339336
• ENSP00000341013
• ENSG00000187689
• ENST00000504451
• ENSP00000422452

Symbol

• AI3B
• UNQ689

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.57
cell type or tissue	0.54
gene perturbation	0.47
cell line	0.45
cellular component	0.37

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.75   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.75   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diabetic nephropathy	EFO_0000401	1	1	0	32.4	2.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diabetic nephropathy	EFO_0000401	0	32.4	2.2

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	amelotin	VGNC:697	742016
Macaque	amelotin		707054
Mouse	amelotin	MGI:1918671	71421
Rat	amelotin	RGD:1592356	689404
Dog	amelotin	VGNC:37841	611794

Species	Name	OMA	EggNOG	Inparanoid
Chimp	amelotin
Macaque	amelotin
Mouse	amelotin
Rat	amelotin
Dog	amelotin

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q6UX39-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)

Reactome (4)

Metabolism of proteins (R-HSA-392499)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	Post-translational protein phosphorylation	107 targets	R-HSA-8957275
Reactome	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	124 targets	R-HSA-381426

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
Post-translational protein phosphorylation	107 targets	R-HSA-8957275
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	124 targets	R-HSA-381426

Gene Ontology Terms (11)

Components (4)

Processes (7)

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GO Term	Evidence	Assigned by
basement membrane	Inferred from Sequence or structural Similarity (ISS)	HGNC
cell-cell junction	Inferred from Sequence or structural Similarity (ISS)	HGNC
extracellular matrix	Inferred from Sequence or structural Similarity (ISS)	HGNC
endoplasmic reticulum lumen	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (142)

Explore Interacting Targets

1 – 10 of 142

• See Interactions on String-DB

LRRC40

Tdark

Novelty:  2.43377466

p_int:  0.911833113

p_ni:  0.087648176

p_wrong:  0.000518711

Score:  0.169

Data Source:  BioPlex,STRINGDB

SEC24D

Tbio

Novelty:  0.04795527

p_int:  0.883337062

p_ni:  0.116113738

p_wrong:  0.0005492

Score:  0.221

Data Source:  BioPlex,STRINGDB

PTPN1

Tchem

Family:  Enzyme

Novelty:  0.00065779

p_int:  0.877835361

p_ni:  0.122109527

p_wrong:  0.000055112

Score:  0.173

Data Source:  BioPlex,STRINGDB

RABL6

Tbio

Family:  Enzyme

Novelty:  0.11501478

p_int:  0.863122708

p_ni:  0.10557725

p_wrong:  0.031300042

Score:  0.19

Data Source:  BioPlex,STRINGDB

NARS

Tbio

Family:  Enzyme

Novelty:  0.01124207

p_int:  0.816597676

p_ni:  0.131236017

p_wrong:  0.052166307

Data Source:  BioPlex

CYB5R3

Tbio

Family:  Enzyme

Novelty:  0.00774258

p_int:  0.798670293

p_ni:  0.201329705

p_wrong:  2e-9

Data Source:  BioPlex

PPID

Tchem

Family:  Enzyme

Novelty:  0.01068886

p_int:  0.796564206

p_ni:  0.057192544

p_wrong:  0.14624325

Score:  0.188

Data Source:  BioPlex,STRINGDB

CDK5RAP3

Tbio

Novelty:  0.03628071

p_int:  0.758779359

p_ni:  0.241028675

p_wrong:  0.000191966

Score:  0.173

Data Source:  BioPlex,STRINGDB

GINS4

Tbio

Novelty:  0.0316194

p_int:  0.757598432

p_ni:  0.242298984

p_wrong:  0.000102584

Score:  0.19

Data Source:  BioPlex,STRINGDB

ENAM

Tbio

Novelty:  0.00593293

Score:  0.989

Data Source:  STRINGDB

Publication Statistics

PubMed Score  44.75

PubMed score by year

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PubTator Score  8.17

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Amelogenesis imperfecta
Biomineralization
Cell adhesion
Complete proteome
Direct protein sequencing
Glycoprotein
Polymorphism
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
diabetic nephropathy

MGI Phenotype Find Similar Targets

No Header	No Header
craniofacial phenotype
growth/size/body region phenotype
skeleton phenotype