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Tbio
VSTM1
V-set and transmembrane domain-containing protein 1

Protein Summary
Description
Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17). Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338372
  • ENSP00000343366
  • ENSG00000189068
  • ENST00000376626
  • ENSP00000365813
  • ENST00000447872
  • ENSP00000401926
  • ENST00000610629
  • ENSP00000482197
  • ENSG00000274953
  • ENST00000610794
  • ENSP00000478582
  • ENSG00000276159
  • ENST00000610804
  • ENSP00000480533
  • ENSG00000274887
  • ENST00000611293
  • ENSP00000482555
  • ENSG00000275330
  • ENST00000612105
  • ENSP00000483412
  • ENSG00000275577
  • ENST00000612436
  • ENSP00000482985
  • ENSG00000276066
  • ENST00000612864
  • ENSP00000481977
  • ENSG00000275962
  • ENST00000613042
  • ENSP00000479748
  • ENST00000615235
  • ENSP00000479198
  • ENSG00000277607
  • ENST00000615508
  • ENSP00000484886
  • ENST00000616717
  • ENSP00000480383
  • ENST00000617115
  • ENSP00000481140
  • ENST00000617281
  • ENSP00000480547
  • ENST00000617776
  • ENSP00000484699
  • ENST00000617862
  • ENSP00000484844
  • ENSG00000276363
  • ENST00000619024
  • ENSP00000483411
  • ENST00000619921
  • ENSP00000483797
  • ENST00000620474
  • ENSP00000484806
  • ENST00000622762
  • ENSP00000483104

Symbol
  • SIRL1
  • SIRL-1
  • UNQ3033
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.56
tissue
0.54
protein domain
0.41
biological term
0.34
cellular component
0.33


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.14   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.14   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0