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Tbio
OLFM4
Olfactomedin-4

Protein Summary
Description
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219022
  • ENSP00000219022
  • ENSG00000102837

Symbol
  • GW112
  • GC1
  • OLM4
  • OlfD
  • GW112
  • hGC-1
  • hOLfD
  • UNQ362
  • bA209J19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
gene perturbation
0.77
virus perturbation
0.64
biological process
0.55
cellular component
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.08   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.08   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (157)
FAAP100
Tdark
Novelty:  0.1698504
p_int:  0.9970647
p_ni:  0.002935297
p_wrong:  3e-9
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.99668274
p_ni:  0.003296186
p_wrong:  0.000021073
Data Source:  BioPlex
RBPMS
Tbio
Novelty:  0.01727259
p_int:  0.995719758
p_ni:  0.004137939
p_wrong:  0.000142303
Data Source:  BioPlex
MTFR1L
Tdark
Novelty:  3.23781609
p_int:  0.991353832
p_ni:  0.008644464
p_wrong:  0.000001705
Score:  0.169
Data Source:  BioPlex,STRINGDB
INTS6
Tbio
Novelty:  0.02680242
p_int:  0.987675226
p_ni:  0.012115964
p_wrong:  0.00020881
Score:  0.21
Data Source:  BioPlex,STRINGDB
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.978272957
p_ni:  0.015073518
p_wrong:  0.006653525
Data Source:  BioPlex
NID2
Tbio
Novelty:  0.01638372
p_int:  0.978068986
p_ni:  0.010882417
p_wrong:  0.011048597
Score:  0.186
Data Source:  BioPlex,STRINGDB
P3H3
Tbio
Family:  Enzyme
Novelty:  0.0010004
p_int:  0.963589612
p_ni:  0.036410388
Data Source:  BioPlex
ERF
Tbio
Family:  TF
Novelty:  0.00182385
p_int:  0.930679042
p_ni:  0.069320945
p_wrong:  1.3e-8
Data Source:  BioPlex
GNL3L
Tbio
Novelty:  0.16432364
p_int:  0.919191609
p_ni:  0.080808391
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
2
5.5
92.5
1
1
0
1
75.9
depressive symptom measurement
2
2
2
70.4
insomnia measurement
1
1
0
1
36.5
intelligence
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
5.5
92.5
0
1
75.9
depressive symptom measurement
2
70.4
insomnia measurement
0
1
36.5
intelligence
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
olfactomedin 4
VGNC:5087
467367
Macaque
olfactomedin 4
694574
Mouse
MGI:2685142
380924
Rat
RGD:1311708
290409
Dog
olfactomedin 4
VGNC:49706
485470
Species
Name
OMA
EggNOG
Inparanoid
Chimp
olfactomedin 4
Macaque
olfactomedin 4
Mouse
Rat
Dog
olfactomedin 4
Publication Statistics
PubMed Score 116.08
PubMed score by year
PubTator Score 87.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title