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Tbio
OLFM4
Olfactomedin-4

Protein Summary
Description
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219022
  • ENSP00000219022
  • ENSG00000102837

Symbol
  • GW112
  • GC1
  • OLM4
  • OlfD
  • GW112
  • hGC-1
  • hOLfD
  • UNQ362
  • bA209J19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
gene perturbation
0.77
virus perturbation
0.64
biological process
0.55
cellular component
0.53


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.18   (req: < 5)
View Publications
Gene RIFs: 43   (req: <= 3)
View Gene RIFs
Antibodies: 235   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.18   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
EFO_0003761
6
3
2
1
98.4
bipolar disorder
EFO_0000289
1
1
0
1
95.7
insomnia measurement
EFO_0007876
1
1
0
1
55.5
autism spectrum disorder
EFO_0003756
1
1
1
51.5
self reported educational attainment
EFO_0004784
1
1
1
22.7
Items per page:
1 – 5 of 7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
EFO_0003761
2
1
98.4
bipolar disorder
EFO_0000289
0
1
95.7
insomnia measurement
EFO_0007876
0
1
55.5
autism spectrum disorder
EFO_0003756
1
51.5
self reported educational attainment
EFO_0004784
1
22.7
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
2246 targets
R-HSA-168256
Reactome
Innate Immune System
1188 targets
R-HSA-168249
Reactome
Neutrophil degranulation
543 targets
R-HSA-6798695
Name
Explore in Pharos
Explore in Source
Immune System
2246 targets
R-HSA-168256
Innate Immune System
1188 targets
R-HSA-168249
Neutrophil degranulation
543 targets
R-HSA-6798695
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
cadherin binding
Inferred from Mutant Phenotype (IMP)
UniProtKB
protein homodimerization activity
Inferred from Mutant Phenotype (IMP)
UniProtKB
catalytic activity
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (157)
1 – 10 of 157
FAAP100
Tdark
Novelty: 0.1698504
p_int: 0.9970647
p_ni: 0.002935297
p_wrong: 3e-9
Data Source: BioPlex
DHFR2
Tbio
Family: Enzyme
Novelty: 0.02374466
p_int: 0.99668274
p_ni: 0.003296186
p_wrong: 0.000021073
Data Source: BioPlex
RBPMS
Tbio
Novelty: 0.01727259
p_int: 0.995719758
p_ni: 0.004137939
p_wrong: 0.000142303
Data Source: BioPlex
MTFR1L
Tdark
Novelty: 3.23781609
p_int: 0.991353832
p_ni: 0.008644464
p_wrong: 0.000001705
Score: 0.169
Data Source: BioPlex,STRINGDB
INTS6
Tbio
Novelty: 0.02680242
p_int: 0.987675226
p_ni: 0.012115964
p_wrong: 0.00020881
Score: 0.21
Data Source: BioPlex,STRINGDB
FUT11
Tbio
Family: Enzyme
Novelty: 0.16098097
p_int: 0.978272957
p_ni: 0.015073518
p_wrong: 0.006653525
Data Source: BioPlex
NID2
Tbio
Novelty: 0.01638372
p_int: 0.978068986
p_ni: 0.010882417
p_wrong: 0.011048597
Score: 0.186
Data Source: BioPlex,STRINGDB
P3H3
Tbio
Family: Enzyme
Novelty: 0.0010004
p_int: 0.963589612
p_ni: 0.036410388
Data Source: BioPlex
ERF
Tbio
Family: TF
Novelty: 0.00182385
p_int: 0.930679042
p_ni: 0.069320945
p_wrong: 1.3e-8
Data Source: BioPlex
GNL3L
Tbio
Novelty: 0.16432364
p_int: 0.919191609
p_ni: 0.080808391
Score: 0.169
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  113.18

PubMed score by year
PubTator Score  87.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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