Protein Summary
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
- ENST00000219022
- ENSP00000219022
- ENSG00000102837
- GW112
- GC1
- OLM4
- OlfD
- GW112
- hGC-1
- hOLfD
- UNQ362
- bA209J19.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.85 | ||
gene perturbation | 0.77 | ||
virus perturbation | 0.64 | ||
biological process | 0.55 | ||
cellular component | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.08 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 235 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.08 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 235 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (157)
FAAP100
Novelty: 0.1698504
p_int: 0.9970647
p_ni: 0.002935297
p_wrong: 3e-9
Data Source: BioPlex
DHFR2
Family: Enzyme
Novelty: 0.02374466
p_int: 0.99668274
p_ni: 0.003296186
p_wrong: 0.000021073
Data Source: BioPlex
RBPMS
Novelty: 0.01727259
p_int: 0.995719758
p_ni: 0.004137939
p_wrong: 0.000142303
Data Source: BioPlex
MTFR1L
Novelty: 3.23781609
p_int: 0.991353832
p_ni: 0.008644464
p_wrong: 0.000001705
Score: 0.169
Data Source: BioPlex,STRINGDB
INTS6
Novelty: 0.02680242
p_int: 0.987675226
p_ni: 0.012115964
p_wrong: 0.00020881
Score: 0.21
Data Source: BioPlex,STRINGDB
FUT11
Family: Enzyme
Novelty: 0.16098097
p_int: 0.978272957
p_ni: 0.015073518
p_wrong: 0.006653525
Data Source: BioPlex
NID2
Novelty: 0.01638372
p_int: 0.978068986
p_ni: 0.010882417
p_wrong: 0.011048597
Score: 0.186
Data Source: BioPlex,STRINGDB
ERF
Family: TF
Novelty: 0.00182385
p_int: 0.930679042
p_ni: 0.069320945
p_wrong: 1.3e-8
Data Source: BioPlex
GNL3L
Novelty: 0.16432364
p_int: 0.919191609
p_ni: 0.080808391
Score: 0.169
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (9)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 5 | 2 | 5.5 | 92.5 | |||||
1 | 1 | 0 | 1 | 75.9 | |||||
depressive symptom measurement | 2 | 2 | 2 | 70.4 | |||||
insomnia measurement | 1 | 1 | 0 | 1 | 36.5 | ||||
intelligence | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 5.5 | 92.5 | |||||
0 | 1 | 75.9 | |||||
depressive symptom measurement | 2 | 70.4 | |||||
insomnia measurement | 0 | 1 | 36.5 | ||||
intelligence | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | olfactomedin 4 | VGNC:5087 | 467367 | |||||
Macaque | olfactomedin 4 | 694574 | ||||||
Mouse | MGI:2685142 | 380924 | ||||||
Rat | RGD:1311708 | 290409 | ||||||
Dog | olfactomedin 4 | VGNC:49706 | 485470 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | olfactomedin 4 | |||||
Macaque | olfactomedin 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | olfactomedin 4 | |||||
Publication Statistics
PubMed Score 116.08
PubMed score by year
PubTator Score 87.97
PubTator score by year
Related Publications
Text Mined References (62)
GeneRif Annotations (43)
Items per page:
0 of 0
PMID | Year | Title |
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