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Tbio
CWC27
Spliceosome-associated protein CWC27 homolog

Protein Summary
Description
As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381070
  • ENSP00000370460
  • ENSG00000153015

Symbol
  • SDCCAG10
  • RPSKA
  • NY-CO-10
  • SDCCAG10
  • SDCCAG-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
histone modification site profile
0.76
tissue sample
0.74
transcription factor binding site profile
0.69
interacting protein
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.48   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.48   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (258)
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.993642566
p_ni:  0.006357434
Data Source:  BioPlex
EDA
Tbio
Novelty:  0.00352464
p_int:  0.972886782
p_ni:  0.027113218
Score:  0.185
Data Source:  BioPlex,STRINGDB
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.942572802
p_ni:  0.057427198
Data Source:  BioPlex
IGSF6
Tbio
Novelty:  0.05015035
p_int:  0.925275091
p_ni:  0.074724909
Score:  0.309
Data Source:  BioPlex,STRINGDB
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.892171351
p_ni:  0.107828649
Score:  0.181
Data Source:  BioPlex,STRINGDB
SNW1
Tbio
Novelty:  0.01423797
Score:  0.998
Data Source:  STRINGDB
DHX16
Tbio
Family:  Enzyme
Novelty:  0.02678951
Score:  0.994
Data Source:  STRINGDB
DHX38
Tbio
Family:  Enzyme
Novelty:  0.01939445
Score:  0.993
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.992
Data Source:  STRINGDB
CWC22
Tbio
Novelty:  0.027689
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
70.4
urinary albumin to creatinine ratio
3
3
3
55.2
1
1
0
1.4
46.9
central corneal thickness
2
1
0
2.5
46.5
cognitive function measurement
3
1
3
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
70.4
urinary albumin to creatinine ratio
3
55.2
0
1.4
46.9
central corneal thickness
0
2.5
46.5
cognitive function measurement
3
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CWC27 spliceosome associated protein homolog
VGNC:6854
461846
Macaque
peptidyl-prolyl cis-trans isomerase CWC27 homolog
100430842
Mouse
MGI:1914535
67285
Rat
RGD:1310697
361887
Dog
CWC27 spliceosome associated protein homolog
VGNC:39743
478076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CWC27 spliceosome associated protein homolog
Macaque
peptidyl-prolyl cis-trans isomerase CWC27 homolog
Mouse
Rat
Dog
CWC27 spliceosome associated protein homolog
Publication Statistics
PubMed Score 6.48
PubMed score by year
PubTator Score 3.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title