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Tbio
ABRAXAS1
BRCA1-A complex subunit Abraxas 1

Protein Summary
Description
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321945
  • ENSP00000369857
  • ENSG00000163322

Symbol
  • ABRA1
  • CCDC98
  • FAM175A
  • ABRA1
  • CCDC98
  • FAM175A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.13   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.13   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
BABAM1
Tbio
Novelty:  0.03812501
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty:  0.01845286
p_int:  0.999989083
p_ni:  0.000003011
p_wrong:  0.000007907
Data Source:  BioPlex
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.999969418
p_ni:  0.000030582
Data Source:  BioPlex
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999215159
p_ni:  0.00078483
p_wrong:  1.1e-8
Data Source:  BioPlex
TEKT4
Tbio
Novelty:  0.05559086
p_int:  0.995758664
p_ni:  0.000045505
p_wrong:  0.004195832
Score:  0.188
Data Source:  BioPlex,STRINGDB
WTAP
Tbio
Novelty:  0.01491546
p_int:  0.899636285
p_ni:  0.100363715
Score:  0.519
Data Source:  BioPlex,STRINGDB
LAMC1
Tbio
Novelty:  0.01230796
p_int:  0.848421637
p_ni:  0.151578363
Score:  0.309
Data Source:  BioPlex,STRINGDB
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
p_int:  0.822230408
p_ni:  0.174911637
p_wrong:  0.002857955
Score:  0.197
Data Source:  BioPlex,STRINGDB
BARD1
Tbio
Novelty:  0.00513841
Score:  0.999
Data Source:  STRINGDB
BRCC3
Tbio
Family:  Enzyme
Novelty:  0.04661632
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
75.1
heel bone mineral density
2
1
2
56.6
upper aerodigestive tract neoplasm
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
75.1
heel bone mineral density
2
56.6
upper aerodigestive tract neoplasm
0
1.1
24.5
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1917931
70681
Cow
abraxas 1, BRCA1 A complex subunit
VGNC:53684
504796
Zebrafish
ZDB-GENE-041010-70
449820
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
abraxas 1, BRCA1 A complex subunit
Zebrafish
Publication Statistics
PubMed Score 10.13
PubMed score by year
PubTator Score 6.60
PubTator score by year
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Related Publications
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PMID
Year
Title