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Tbio
ARSK
Arylsulfatase K

Protein Summary
Description
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380009
  • ENSP00000369346
  • ENSG00000164291

Symbol
  • TSULF
  • TSULF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.76
transcription factor binding site profile
0.7
cell type or tissue
0.57
gene perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
79.9
1
1
0
1.1
8.6
pulmonary function measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
79.9
0
1.1
8.6
pulmonary function measurement
1
3.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase family member K
VGNC:11830
461745
Mouse
MGI:1924291
77041
Rat
RGD:1310182
365619
Dog
arylsulfatase family member K
VGNC:38146
488903
Horse
arylsulfatase family member K
VGNC:15551
100073230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase family member K
Mouse
Rat
Dog
arylsulfatase family member K
Horse
arylsulfatase family member K
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6UWY0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (75)
1 – 10 of 75
ATG2B
Tbio
Novelty:  0.04963717
p_int:  0.996886902
p_ni:  0.003112742
p_wrong:  3.57e-7
Data Source:  BioPlex
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.995746565
p_ni:  0.004253435
Score:  0.257
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.995657275
p_ni:  0.004342725
Data Source:  BioPlex
ZNF621
Tdark
Family:  TF
Novelty:  1.96460285
p_int:  0.995555696
p_ni:  7e-9
p_wrong:  0.004444296
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.992094068
p_ni:  0.007905917
p_wrong:  1.5e-8
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.991756925
p_ni:  0.008243074
p_wrong:  1e-9
Data Source:  BioPlex
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.991154573
p_ni:  0.008845416
p_wrong:  1.1e-8
Data Source:  BioPlex
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.990752457
p_ni:  0.00924754
p_wrong:  3e-9
Data Source:  BioPlex
CST9L
Tdark
Novelty:  0.21941207
p_int:  0.989399466
p_ni:  0.010600534
Data Source:  BioPlex
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.98866581
p_ni:  0.011334092
p_wrong:  9.8e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  11.02

PubMed score by year
PubTator Score  183.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer