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Tbio
ENPP7
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Protein Summary
Description
Converts sphingomyelin to ceramide and phosphocholine (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:28292932). Has also phospholipase C activity and can cleave phosphocholine from palmitoyl lyso-phosphatidylcholine (PubMed:12885774). Does not have nucleotide pyrophosphatase activity (PubMed:12885774). The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328313
  • ENSP00000332656
  • ENSG00000182156

Symbol
  • NPP7
  • NPP-7
  • E-NPP 7
  • ALK-SMase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.62
biological process
0.6
cell line
0.58
cellular component
0.55


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.93   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.93   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleotide pyrophosphatase/phosphodiesterase 7
VGNC:9273
742055
Macaque
ectonucleotide pyrophosphatase/phosphodiesterase 7
717416
Mouse
MGI:3027917
238011
Rat
RGD:1359324
303729
Dog
ectonucleotide pyrophosphatase/phosphodiesterase 7
VGNC:40378
608627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleotide pyrophosphatase/phosphodiesterase 7
Macaque
ectonucleotide pyrophosphatase/phosphodiesterase 7
Mouse
Rat
Dog
ectonucleotide pyrophosphatase/phosphodiesterase 7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (48)
1 – 10 of 48
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999981271
p_ni: 0.000018728
Score: 0.152
Data Source: BioPlex,STRINGDB
EPDR1
Tbio
Novelty: 0.03597825
p_int: 0.999850481
p_ni: 0.000147085
p_wrong: 0.000002434
Score: 0.189
Data Source: BioPlex,STRINGDB
CD109
Tbio
Novelty: 0.01280272
p_int: 0.971453008
p_ni: 0.028546992
Data Source: BioPlex
ERGIC2
Tbio
Novelty: 0.08610944
p_int: 0.916545716
p_ni: 0.083454284
Score: 0.193
Data Source: BioPlex,STRINGDB
RHEB
Tbio
Family: Enzyme
Novelty: 0.00313935
p_int: 0.871650326
p_ni: 0.12799878
p_wrong: 0.000350894
Score: 0.186
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.859968271
p_ni: 0.140031729
Data Source: BioPlex
MKS1
Tbio
Novelty: 0.02463305
p_int: 0.796261355
p_ni: 0.202077428
p_wrong: 0.001661217
Score: 0.158
Data Source: BioPlex,STRINGDB
TTC17
Tdark
Novelty: 0.79373597
p_int: 0.786895125
p_ni: 0.213104875
Data Source: BioPlex
PDF
Tchem
Family: Enzyme
Novelty: 0.02477934
p_int: 0.782796952
p_ni: 0.217203048
Score: 0.217
Data Source: BioPlex,STRINGDB
CERK
Tchem
Family: Kinase
Novelty: 0.0103948
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.93

PubMed score by year
PubTator Score  17.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer