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Tbio
LCLAT1
Lysocardiolipin acyltransferase 1

Protein Summary
Description
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309052
  • ENSP00000310551
  • ENSG00000172954
  • ENST00000319406
  • ENSP00000368826
  • ENST00000379509
  • ENSP00000368823

Symbol
  • AGPAT8
  • ALCAT1
  • LYCAT
  • LYCAT
  • AGPAT8
  • ALCAT1
  • 1AGPAT8
  • UNQ1849
  • HSRG1849
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
microRNA
0.77
kinase perturbation
0.76
cell type or tissue
0.71
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0