You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPINK6
Serine protease inhibitor Kazal-type 6

Protein Summary
Description
Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325630
  • ENSP00000324870
  • ENSG00000178172
  • ENST00000621437
  • ENSP00000481309

Symbol
  • BUSI2
  • UNQ844
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.48
cell line
0.47
biological term
0.35
drug
0.35
transcription factor
0.34


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
KLK14
Tchem
Family:  Enzyme
Novelty:  0.02007434
Score:  0.968
Data Source:  Reactome,STRINGDB
KLK13
Tchem
Family:  Enzyme
Novelty:  0.01963129
Score:  0.949
Data Source:  Reactome,STRINGDB
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
Score:  0.949
Data Source:  Reactome,STRINGDB
KLK12
Tbio
Family:  Enzyme
Novelty:  0.02417383
Score:  0.948
Data Source:  Reactome,STRINGDB
SPINK5
Tbio
Family:  Enzyme
Novelty:  0.00451563
Score:  0.749
Data Source:  STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
Score:  0.731
Data Source:  STRINGDB
SPINK7
Tbio
Family:  Enzyme
Novelty:  0.02397234
Score:  0.695
Data Source:  STRINGDB
PPDPFL
Tdark
Novelty:  3.16137791
Score:  0.692
Data Source:  STRINGDB
SPINK4
Tdark
Family:  Enzyme
Novelty:  0.06706505
Score:  0.614
Data Source:  STRINGDB
SPINK1
Tbio
Family:  Enzyme
Novelty:  0.00074416
Score:  0.584
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kazal type 6
VGNC:4175
741114
Mouse
MGI:3648654
433180
Rat
RGD:1303338
408235
Dog
serine peptidase inhibitor, Kazal type 6
VGNC:53475
100685732
Horse
serine protease inhibitor Kazal-type 6
100630872
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine peptidase inhibitor, Kazal type 6
Mouse
Rat
Dog
serine peptidase inhibitor, Kazal type 6
Horse
serine protease inhibitor Kazal-type 6
Publication Statistics
PubMed Score 11.68
PubMed score by year
PubTator Score 39.16
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title