Tbio SPINK6 Serine protease inhibitor Kazal-type 6

Protein Summary

Description

Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q6UWN8
• E0X656
• Q8N5P0

Gene Name

• SPINK6

Ensembl ID

• ENST00000325630
• ENSP00000324870
• ENSG00000178172
• ENST00000621437
• ENSP00000481309

Symbol

• BUSI2
• UNQ844

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.48
cell line	0.47
biological term	0.35
drug	0.35
transcription factor	0.34

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor Kazal-type 6

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor Kazal-type 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.67   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.67   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0