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Tdark
TMCO3
Transmembrane and coiled-coil domain-containing protein 3

Protein Summary
Description
Probable Na(+)/H(+) antiporter. This gene encodes a member of the monovalent cation:proton antiporter 2 (CPA2) family of transporter proteins. Members of this family typically couple the export of monovalent cations, such as potassium or sodium, to the import of protons across cellular membranes. Mutations in this gene have been identified in patients with a rare inherited vision defect, cornea guttata with anterior polar cataract. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375391
  • ENSP00000364540
  • ENSG00000150403
  • ENST00000434316
  • ENSP00000389399
  • ENST00000474393
  • ENSP00000484053

Symbol
  • C13orf11
  • C13orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.79
transcription factor binding site profile
0.74
kinase perturbation
0.71
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
79.2
neutrophil count
1
1
1
78.7
leukocyte count
1
1
1
43.8
neutrophil percentage of leukocytes
1
1
1
28.7
electrocardiography
1
1
2
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
79.2
neutrophil count
1
78.7
leukocyte count
1
43.8
neutrophil percentage of leukocytes
1
28.7
electrocardiography
2
11.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane and coiled-coil domains 3
VGNC:5123
452681
Mouse
MGI:2444946
234076
Rat
RGD:1306586
306607
Rat
RGD:9333008
103693999
Dog
transmembrane and coiled-coil domains 3
VGNC:47433
485556
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane and coiled-coil domains 3
Mouse
Rat
Rat
Dog
transmembrane and coiled-coil domains 3
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (82)
1 – 10 of 82
TAP2
Tbio
Novelty: 0.0390555
p_int: 0.999547599
p_ni: 0.000452317
p_wrong: 8.4e-8
Score: 0.221
Data Source: BioPlex,STRINGDB
FNDC5
Tbio
Novelty: 0.0015827
p_int: 0.998775491
p_ni: 0.000442732
p_wrong: 0.000781777
Data Source: BioPlex
COG4
Tbio
Novelty: 0.03809668
p_int: 0.998611927
p_ni: 0.001388073
Data Source: BioPlex
IFT57
Tbio
Novelty: 0.03373199
p_int: 0.998302991
p_ni: 0.000331459
p_wrong: 0.00136555
Data Source: BioPlex
HEMK1
Tbio
Family: Enzyme
Novelty: 0.03509926
p_int: 0.997834426
p_ni: 0.000452859
p_wrong: 0.001712715
Score: 0.336
Data Source: BioPlex,STRINGDB
SLC25A17
Tbio
Family: Transporter
Novelty: 0.00601179
p_int: 0.995132009
p_ni: 0.004867991
Score: 0.157
Data Source: BioPlex,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
p_int: 0.993254088
p_ni: 0.006745911
p_wrong: 1e-9
Data Source: BioPlex
PSME2
Tbio
Novelty: 0.02624268
p_int: 0.992646573
p_ni: 0.007344814
p_wrong: 0.000008613
Data Source: BioPlex
ATG9A
Tbio
Novelty: 0.01995033
p_int: 0.984012618
p_ni: 0.015986028
p_wrong: 0.000001355
Data Source: BioPlex
PXMP2
Tbio
Novelty: 0.24472872
p_int: 0.969767088
p_ni: 0.030232911
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  1.12

PubMed score by year
PubTator Score  1.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer