Tbio IL27RA Interleukin-27 receptor subunit alpha

Protein Summary

Description

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6UWB1
• A0N0L1
• O60624
• IL-27 receptor subunit alpha

Gene Name

• IL27RA

Ensembl ID

• ENST00000263379
• ENSP00000263379
• ENSG00000104998

Symbol

• CRL1
• TCCR
• WSX1
• CRL1
• TCCR
• WSX1
• IL27R
• IL-27RA
• zcytor1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
PubMedID	0.7
histone modification site profile	0.69
tissue sample	0.64
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin-27 Receptor Subunit Alpha

Protein / Defense/immunity Protein / Interleukin-27 Receptor Subunit Alpha

DTO Classes

Protein / Signaling / Cytokine / Interleukin-27 Receptor Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.14   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 443   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.14   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 443   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0