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Tbio
IL27RA
Interleukin-27 receptor subunit alpha

Protein Summary
Description
Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263379
  • ENSP00000263379
  • ENSG00000104998

Symbol
  • CRL1
  • TCCR
  • WSX1
  • CRL1
  • TCCR
  • WSX1
  • IL27R
  • IL-27RA
  • zcytor1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
PubMedID
0.7
histone modification site profile
0.69
tissue sample
0.64
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.13   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 443   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.13   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 443   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
32.6
lymphocyte count
1
1
1
29.6
monocyte count
1
1
1
29.6
lymphocyte percentage of leukocytes
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
32.6
lymphocyte count
1
29.6
monocyte count
1
29.6
lymphocyte percentage of leukocytes
1
25.4
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-27 signaling
Reactome
Interleukin-35 Signalling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-27 signaling
Interleukin-35 Signalling
Protein-Protein Interactions (122)
1 – 10 of 122
POTEE
Tbio
Novelty: 0.29349205
p_int: 0.999998521
p_ni: 0.000001478
p_wrong: 1e-9
Data Source: BioPlex
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.99995029
p_ni: 0.00004971
Data Source: BioPlex
TMX4
Tdark
Novelty: 0.2628295
p_int: 0.99958574
p_ni: 0.00041426
Data Source: BioPlex
DNAJC18
Tdark
Novelty: 1.38573997
p_int: 0.998578355
p_ni: 0.001421645
Data Source: BioPlex
FNDC3A
Tbio
Novelty: 0.04721453
p_int: 0.99844804
p_ni: 0.00155196
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.997499762
p_ni: 0.00249539
p_wrong: 0.000004847
Data Source: BioPlex
DEPDC1
Tbio
Novelty: 0.04255829
p_int: 0.997096129
p_ni: 0.002758247
p_wrong: 0.000145624
Data Source: BioPlex
ULBP3
Tbio
Novelty: 0.0320239
p_int: 0.995591319
p_ni: 0.004408615
p_wrong: 6.7e-8
Data Source: BioPlex
B4GALT5
Tbio
Family: Enzyme
Novelty: 0.04538678
p_int: 0.995107622
p_ni: 0.003942999
p_wrong: 0.000949379
Data Source: BioPlex
RHBDD3
Tbio
Novelty: 0.04564748
p_int: 0.992760234
p_ni: 0.00723976
p_wrong: 6e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  94.13

PubMed score by year
PubTator Score  51.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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